Lupus Dr Higgins-
What is SLE or Lupus?
an autoinmune disease associated with antibody production
What gender is more affected by Lupus?
Women
What is affected in the pathophysiology for lupus?
T and B lymphocyte activation and signaling
Which cells increase and develop autoantibodies that damage host tissue?
PlasmaB cells
What is a positive result for autoantibodies?
1:40
1:1280
What are the EULAR Clinical Domains?
Mucocutaneous
musculoskeletal serosal renal
neuropsychiatric
hematologic
constitutional
What are some Nonpharmacologic Theraphy?
Wear protective clothing and hat
use sunscreens
good social support
Exercise
How is the clinical presentation of Lupus in CNS?
cognitive, psychosis, seizures, fever
How is the clinical presentation of Lupus in Lungs
Pneumonia, Peluritis
How is the clinical presentation of Lupus in Blood?
blood clots, anemia
How is the clinical presentation of Lupus in Mouth?
oral ulcers
How is the clinical presentation of Lupus in Joints/Muscle?
arthritis
How is the clinical presentation of Lupus in Kidney?
Nephritis, renal failure
, How is the clinical presentation of Lupus in Heart?
heart murmurs
How is the clinical presentation of Lupus in Skin/Hair?
Photosensitivity, malar rash , alopecia, discoid rash
What are the FDA approved drugs for SLE?
Aspirin
prednisone
hydroxychloriquine
belimumab
anifrolumab-fri
voclosporin
How is the clinical presentation of Lupus in Heart?
heart murmurs
When should anti-malarial be given in SLE?
in all types
When are immunosuppressants involved/need ?
When organs are involved, or disease is uncontrolled
What are the contraindications for NSAIDS in lupus?
Avoid if have Severe lupus and kidney disease
What monitoring labs should be watched?
CBC, platelets, AST/ALT, BP, creatinine, urinalysis
What are glucocorticoids drug used in severe lupus?
Prednisone oral or IV methylprednisolone
What is pulse therapy?
4-6 weeks of therapy then tapered to maintenance
Risk when used glucorticoids
increasing neuropsichiatric lupus
What are the anti-malarial drugs?
Chlroquine
Hydroxychloroquine (Plaquenil)
What is the MOA of anti-malarials?
reduces cytokines and alters antigen presentation. Also affects T cell proliferation
response. Reduces platelet aggregation and thrombosis
Antimalarial dosing
200-400mg daily
What are the biological agents?
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