100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Sinovac Information Pack Case study: Sinovac’s PiCoVacc COVID-19 vaccine £6.39   Add to cart

Exam (elaborations)

Sinovac Information Pack Case study: Sinovac’s PiCoVacc COVID-19 vaccine

 5 views  0 purchase

Sinovac Information Pack Case study: Sinovac’s PiCoVacc COVID-19 vaccine

Preview 4 out of 55  pages

  • June 21, 2024
  • 55
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers
All documents for this subject (55)
avatar-seller
ACTUALSTUDY
Case study: Sinovac’s PiCoVacc COVID-19 vaccine Phase 3 Ongoing


R&D commencement: January 2
In-clinic: Humans dosed: 744 (expected Pha
Phase II Funding disclosed: N/A
Vaccine type: Inactivated vaccin

Asset overview

 PiCoVacc is a COVID-19 vaccine candidate based on a chemically inactivated formulation of the SARS-CoV-2 virus developed by Sinovac
 PiCoVacc uses a proven formulation that induces a SARS-CoV-2-specific neutralizing antibody response, conferring immunity
 Sinovac has partnered with Dynavax to use their CPG 1018 adjuvant, which boosts the immune response to inactivated vaccines (e.g., HEPLIS


Development timeline

 Sinovac announced the beginning of a combined Phase I/Phase II clinical trial on April 20, 2020
 Sinovac recently expanded its manufacturing capabilities by acquiring space and funding; over 70K square meters of land were acquired in add
to funding from the Bank of Beijing to prepare for scaled production


Reasons for optimism
 The antibodies generated by PiCoVacc appear to be effective against multiple known mutations of the virus, and have shown promise in trials o
macaques
 No evidence of antibody-dependent enhancement, an occasional side effect in which some antibodies generated by a vaccine can be beneficia
the virus

, Phase 3 Ong

Case study: Sinopharm/Wuhan Institute of Virology’s inactivated vaccine can
R&D commencement: Q1 202
In-clinic: Humans dosed: 96 (expected Pha
Phase II Funding disclosed: $141M
Vaccine type: Inactivated vaccin
Asset overview
 The COVID-19 vaccine candidate developed by Sinopharm/Wuhan Institute of Virology is based on an inactivated formulation of the SARS-CoV
virus
 Chinese state-owned pharmaceutical group Sinopharm has partnered with the Wuhan Institute of Virology to co-develop their first inactivated va
which induces a SARS-CoV-2-specific neutralizing antibody response

Development timeline
 First and second phases of the trial for the vaccine candidate were launched in April 2020, with trial participants from the first phase still under
observation
 Chairman of Sinopharm, Liu Jingzhen, stated that a fund of 1B yuan (~$141M) has been set up to support vaccine R&D efforts
 Sinopharm intends to conduct the third phase of the trial and expects that the safety and efficacy study will take one year to complete all three
phases

Reasons for optimism
 Phase I of trials for the vaccine candidate has demonstrated a strong safety profile so far
 Sinopharm’s inactivated vaccine is the third COVID-19 vaccine candidate to be approved in China; once successfully synthesized, inactivated
vaccines can be produced on a large scale while other types of vaccines developed using new technologies are limited due to a lack of product
capacity

, Phase 3 O

Case study: Sinopharm/Beijing Biological Products’ inactivated vaccine candidate

R&D commencement: April 202
In-clinic: Humans dosed: N/A
Phase II Funding disclosed: N/A
Vaccine type: Inactivated vaccin
Asset overview

 The COVID-19 vaccine candidate is based on an inactivated formulation of the SARS-CoV-2 virus (specifically using Vero cells)
 Chinese state-owned pharmaceutical group Sinopharm has partnered with Beijing Tiantan Biological Products to co-develop this inactivated vac
(in addition to the vaccine developed in partnership with Wuhan Institute)



Development timeline

 There is little information on the Sinopharm/Beijing Tiantan vaccine partnership; according to the Chinese Clinical Trial Registry, the study regist
was filed at the end of April
 However, Sinopharm has been actively working on other COVID-19 vaccines that can potentially be leveraged for this project



Reasons for optimism

 Sinopharm already has two potential vaccines in the pipeline through partnerships with other institutes in China

,

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller ACTUALSTUDY. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £6.39. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

79650 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£6.39
  • (0)
  Add to cart