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Clinical Pharmacology Test 1 questions and answers

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Clinical Pharmacology Test 1 questions and answers

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  • June 23, 2024
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  • 2023/2024
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Hkane
Clinical Pharmacology Test 1
A drug has a 20 hour half-life. How long will it take for this drug to be considered "cleared"
from the body?

10 hours
50 hours
100 hours
500 hours - correct answer-100 hours

A drug that increases or speeds up the activity on the enzyme is called what?

Synergistic effects
Enzyme inhibition
Enzyme induction
Antagonistic effects - correct answer-Enzyme induction

A measurement of the amount of drug or dose of drug required to produce a given effect

Antagonist
Agonist
Potency
Efficacy - correct answer-Potency

A measurement of the probability that a drug molecule will interact with a receptor. Describes
the tightness of the bond between a drug and a receptor.

Antagonist
Potency
Selectivity
Affinity - correct answer-Affinity

A patient with a history of angina should receive:
I. daily aspirin
II. clopidogrel (Plavix)
III. dipyridamole + aspirin (Aggrenox)
IV. warfarin (Coumadin)

I only
II only
III only
IV only
Either I, II, or III are appropriate - correct answer-Either I, II, or III are appropriate

A patient with a history of myocardial infarction should receive:
I. daily aspirin

,II. clopidogrel (Plavix)
III. dipyridamole + aspirin (Aggrenox)
IV. warfarin

I. Only
II. Only
III. Only
IV. Only
Either I, II, or III are appropriate - correct answer-Either I, II, or III are appropriate

A patient with a history of peripheral vascular disease (PVD) who is allergic to aspirin should
receive:

Daily aspirin
Warfarin (Coumadin)
Clopidogrel (Plavix) - correct answer-Clopidogrel (Plavix)

A patient with a history of recent deep vein thrombosis (DVT) or pulmonary embolism (PE)
should receive:

Daily aspirin
Warfarin (Coumadin)
Clopidogrel (Plavix) - correct answer-Warfarin (Coumadin)

A patient with a history of recent deep vein thrombosis (DVT) or pulmonary embolism (PE)
should receive?

Daily Aspirin
Warfarin (Coumadin)
Clopidogrel (Plavix) - correct answer-Warfarin (Coumadin)

A patient with a prosthetic heart valves should receive:

Daily aspirin
Warfarin (Coumadin)
Clopidogrel (Plavix) - correct answer-Warfarin (Coumadin)

ACE-Inhibitors are beneficial in CHF because they help to block one of the compensatory
mechanisms involved in worsening heart failure.

True
False - correct answer-True

Antihypertensive of choice in patients with congestive heart failure.

Captopril (Capoten)
Amlodipine (Norvasc)
Doxazosin (Cardura) - correct answer-Captopril (Capoten)

, Antihypertensive of choice in patients with diabetes.

Propranolol (Inderal)
Captopril (Capoten)
Furosemide (Lasix)
Amlodipine (Norvasc) - correct answer-Captopril (Capoten)

Antihypertensive of choice in patients with renal failure and fluid overload (edema).


Lisinopril (Zestril)
Propranolol (Inderal)
Prazosin (Minipress)
Furosemide (Lasix) - correct answer-Furosemide (Lasix)

Associated with orthostatic hypotension & first dose syncope.

Captopril (Capoten)
Prazosin (Minipress)
Atenolol (Tenormin) - correct answer-Prazosin (Minipress)

Blocking of alpha 1 receptors in the vasculature of the skin, mucus membranes, and most
organs will cause what physiologic response?

Vasodilation
Vasoconstriction - correct answer-Vasodilation

Blocking of beta 1 receptors will cause what physiologic response?

Increased heart rate
Decreased heart rate - correct answer-Decreased heart rate

Blocking of Beta 2 receptors in the liver will cause what physiologic response?

Increased liver sugar production
Decreased liver sugar production - correct answer-Decreased liver sugar production

Blocking of beta 2 receptors in the lungs will cause what physiologic response?

Bronchodilation
Bronchoconstriction - correct answer-Bronchoconstriction

Blocking of Beta 2 receptors in the vasculature of the skeletal muscles, lungs, and heart will
cause what physiologic response?

Vasodilation
Vasoconstriction - correct answer-Vasoconstriction

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