Acute Tolerance - ANS-You feel more sober when coming down from intoxication
Affinity - ANS-A measure of the degree of attraction between ligand and receptor -
related by Kd, the dissociation constant
Alcohol, in high doses, is a ____
receptor antagonist - ANS-NMDA - this causes blackouts
All opioid receptors are ______ - ANS-Metabotropic
, All schizophrenic drugs are _______ receptor ______. These drugs are known as
______ - ANS-Dopamine receptor antagonists - known as neuroleptics or tranquilizers
Amphetamines can act as DA neurotoxins, especially in the _______ part of the brain. -
ANS-Basal Ganglia
Amygdala - ANS-the emotional significance center of the brain - controls HPA axis
an action potential is a kind of ______ - ANS-EPSP
An autoreceptor agonist functions as an ____ - ANS-antagonist
Auditory cortex is in ____ lobe. Visual cortex is in _____ lobe. Motor cortex is in ____
lobe (occipital, frontal, temporal) - ANS-temporal; occipital; frontal
Behavioral Tolerance - ANS-become able to function while intoxicated
Black widow spider venom triggers the release of ______. This is what kind of
overload? - ANS-triggers a massive release of ACh in the autonomic nervous system -
parasympathetic overload
By blocking the monoamine
TRANSPORTERS, cocaine and amphetamines function as __ Monoamine ___ -
ANS-Indirect Monoamine Agonists
Catecholamine Releasers - allow what to happen? What are they also known as? -
ANS--Allow DA and NE to be released into the synapse without the need of an action
potential
-examples are amphetamines and methamphetamines
-psychomotor stimulants
CB1 receptor location in the synapse - ANS-PREsynaptically
CB1 receptors are all _______, and are negatively coupled to Adenylate Cyclase, which
results in ____. - ANS-metabotropic - hyperpolarization through modulation of K+ and
Ca2+ channels
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