MT AAB Hematology
What is hemoglobin composed of? - ANS-4 heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to? - ANS-porphyria
What is the function of the enzyme methemoglobin-cytochrome C reductase in a red
blood cell? - ANS-to keep iron in the ferrous state
Which hemoglobin has a 200 times greater binding capacity for the hemoglobin
molecule than oxygen? - ANS-carboxyhemoglobin
What product is formed when ferrous iron of hemoglobin is oxidized to the ferric state? -
ANS-methemoglobin
Which hemoglobin derivative causes irreversible changes in the red blood cells? -
ANS-sulfhemoglobin
Which hemoglobin is NOT normally present in a normal adult? - ANS-Hb-S
Which embryonic hemoglobin is normally found in newborns? - ANS-Hb-F
What is the most abundant hemoglobin in a newborn? - ANS-Hb-F
What is the molecular structure of hemoglobin S? - ANS-valine replaces glutamic acid in
the 6th position of the beta chain
Which hemoglobin is insoluble under lowered oxygen tension? - ANS-Hb-S
What laboratory test is used to confirm the specific diagnosis of sickle cell anemia? -
ANS-hemoglobin electrophoresis
In the solubility test for hemoglobin S, what is the reagent responsible for the reduction
of the hemoglobin molecule? - ANS-sodium dithionite
In hemoglobin C, what replaces glutamic acid? - ANS-lysine
Which red blood cell inclusion is characteristic of hemoglobin C disease? -
ANS-rod-shaped crystals
,What is hemoglobin F composed of? - ANS-2 alpha + 2 gamma chains
Which hemoglobin is resistant to alkali denaturation? - ANS-Hb-F
What hemoglobins are differentiated by the Kelihauer-Betke technique? - ANS-Hb-A1
from Hb-F
What is the order of migration of hemoglobins, from fastest to slowest, on cellulose
acetate at pH 8.4? - ANS-A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are identified on cellulose acetate
at pH 8.6? - ANS-It separates hemoglobin S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin pigments EXCEPT which
one? - ANS-sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method for the determination of
hemoglobin? - ANS-Drabkin's solution
What is the normal plasma hemoglobin concentration? - ANS-2-3mg/dL
Which plasma protein binds free hemoglobin? - ANS-haptoglobin
Which statement is false concerning hemolytic anemia? - ANS-The serum haptoglobin
is increased
Which statements are true concerning hemolytic anemia? - ANS-hemolytic anemia is a
normocytic, normochromic anemia
The RBC's, hemoglobin, and hematocrit are decreased
the indirect bilirubin is increased
Myoglobin can be separated from hemoglobin by saturating the specimen with which
reagent? - ANS-ammonium sulfate
The hematocrit is also known as which term? - ANS-packed red blood cell volume
The degree of packing of cells during centrifugation does not depend on what? -
ANS-bore size of the microhematocrit tube
, The degree of packing of cells during centrifugation depends on what? - ANS-speed of
centrifugation
radius of centrifugation
time of centrifugation
During examination of a spun hematocritt, in which layer are the white blood cells
found? - ANS-buffy coat
When performing a microhematocrit, where should one read the percentage of packed
red blood cell column from a microhematocrit reading device? - ANS-below the buffy
coat
An increase in the erythrocyte sedimentation rate can be the result of an increase in the
quantity of what? - ANS-fibrinogen
Which test is increased in acute infections? - ANS-erythrocyte sedimentation rate
Which source of error will not falsely elevate the erythrocyte sedimentation rate? -
ANS-polycythemia
Which sources of error will falsely elevate the ESR? - ANS-tilted tube
macrocytes
vibration
What is the Westergren ESR reference range for males? - ANS-0-15 mm/hr
A cerebrospinal fluid has 285 red blood cells counted in the 5 red blood cell squares
after being diluted in a Unopette (1:100). What is the calculated red blood cell count/µL?
- ANS-1,425,000
Total cells=cells countedXdilution/squaresX10,000
285x100/5x10,000
28500/5x10,000
285x5=1425 1425x100=1425000?????
Any cell that passes through the aperture will momentarily increase the resistance of the
electrical flow between the electrodes, generating a pulse. This is the basic principle of
what? - ANS-electrical impedance
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