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NR546 week 3 test your knowledge quiz
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NR546 week 3 test your knowledge quiz_________ is a defining feature for some psychotic disorders while other disorders may have a
psychotic component - ANS-psychosis
2 dones and a rone - ANS--more potently to the 5HT 2A receptor than to D2 or bine equally
between the 2 receptors.
-less sedating and cause less weight gain, but have a higher risk for hyperprolactinemia and
EPS
2 pips and a rip - ANS--pips: bind more potently to D2 receptors than to 5HT-2A, have low risk
of metabolic side effects and weight gain, but they have a potential for EPS.
-rips binds equally to both D2 and 5HT-2A receptors, have low risk for metabolic disorders
Abnormal Involuntary Movement Scale ( AIMS) - ANS-this tool is used to monitor involuntary
movements and tardive dyskinesia in clients who take antipsychotic medication
-best practice/recommendation to document the AIMS at minimum every 6 months for patients
taking an antipsychotic agent/dopamine blocker
adding 5HT2A antagonism: - ANS-improve side effects of D2 blockade and enhance the
antipsychotic efficacy of D2 blockade
Additional adverse effects of excessive D2 receptor blockade (D2 antagonist actions) include: -
ANS--cardiac concerns: QT prolongation, torsades de pointes, and sudden cardiac death
-blood dyscrasias (neutropenia, leukopenia, and agranulocytosis)
-esophageal dysmotility, aspiration
-increased fall risk
akathisia - ANS-Inner restlessness leading to repetitive motion (rocking, tapping fingers).
Alex is a returning client who reports leaking fluid from his nipples. Which of the following is
most likely responsible for these undesirable side effects? - ANS-Risperidone
-highest risk for galactorrhea, due to hyperprolactinemia.
all forms of psychosis are linked to the neurotransmitter systems: - ANS-dopamine, serotonin,
and glutamate
Alogia - ANS-dysfunction of communication
-poverty of speech
anhedonia - ANS-a diminished ability to experience pleasure
,antipsychotic meds - ANS-primarily used for schizophrenia & psychotic disorders
-also used as adjunctive meds for management of tx-resistant depression & other conditions
-not curative
-decrease/control symptoms/improve quality of life
Antipsychotics are prescribed based on their: - ANS--pharmacological properties
-side effect profiles
-adverse effects according to the unique symptoms and needs of individuals across the lifespan
any abnormal motor symptoms caused by D2 receptor blockers are lumped together and called
collectively: - ANS-extrapyramidal symptsom (EPS)
-motor side effects of D2 antagonists
area of the brain thought to be responsible for the positive symptoms of schizophrenia is the
____________. one of the neuronal pathways known to be affected here is the ___________
from the _____________ and the _____________. - ANS-limbic system, mesolimbic pathway,
ventral tegmental area (VTA), nucleus accumbens
aripiprazole (Abilify) - ANS-Indication: FDA approved for schizophrenia ages 13 and older
Risk:
Low metabolic risk
Low risk for weight gain
Low risk for orthostatic hypotension
asenapine (Saphris) - ANS-Indication: FDA approved for schizophrenia ages 10 and older
Special Comments: Available in sublingual and transdermal patch
Risk:
Low metabolic risk
asociality - ANS-lack of interest in social interactions
avolition - ANS--lack of motivation
-reduced ability to complete everyday tasks
Barnes Akathisia Rating Scale (BARS) - ANS-
bradykinesia - ANS-Slowness of movement
brexpiprazole (Rexulti) - ANS-Indication: FDA approved for schizophrenia
Special Comments: Considered procognitive
, Risk:
Low metabolic risk
cariprazine (Vraylar) - ANS-Indication: FDA approved for schizophrenia
Risk:
Low metabolic risk
Carla is a 35-year-old woman that is currently taking olanzapine for her diagnosed
schizophrenia. She has gained 30 pounds in the last 6 months and her waist circumference is
37 inches. She requests a change in medications. Which of the following medications is less
associated with weight gain?
quetiapine - ANS-aripiprazole
-associated with the lowest risk weight gain.
caused by chronic blockade of D2 receptors in the nigrostriatal dopamine pathway -
ANS-tardive dyskinesia (TD)
-tx: interventions that lower dopamine neurotransmission, inhibiting the vesicular monoamine
transporter type 2 (VMAT2) lowers the "go" signals - deuterated tetrabenazine
(deutetrabenazine), Valbenazine (most selective and potent) ,
Clients are more likely to experience side effects when changing from a medication in one
___________ to a medication in another ____________ - ANS-subcategory, subcategory
(ex: pine to done)
clozapine (Clozaril) - ANS-Indication: Approved for treatment-resistant schizophrenia and
chronic suicidal behavior in schizophrenia or schizoaffective disorder
Not indicated in acute presentation of schizophrenia
Special Comments: The Absolute Neutrophil Count (ANC) must be >1500/mm3 when used and
requires initial and weekly monitoring of WBC, granulocyte, and neutrophil counts.
Risk:
High metabolic risk
Highest risk for weight gain.
Low EPS risk.
Black box warning: may cause severe neutropenia
Contraindicated in liver disease and hepatic failure
Not a first-choice mediation for treating schizophrenia
Commonly prescribed antipsychotic medications for treatment of positive schizophrenic
symptoms - ANS-lowest to highest potency
-chlorpromazine (low)
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