AMR Antibiotics - Exam 1 Questions and Answers 100% Accurate
Penicillins - ANSWER-- Beta lactams; inhibit bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs) which in turn prevents the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. - Exhibit time-dependent killing and bactericidal, except against Entercocci species where aminoglycoside are needed for bactericidal activity
Penicillin G - ANSWER-narrow spectrum penicillin
Penicillin V - ANSWER-narrow spectrum penicillin
Ampicillin - ANSWER-broad spectrum penicillin
Amoxicillin - ANSWER-broad spectrum penicillin
Methicillin - ANSWER-narrow spectrum penicillin
Cephelosporins - ANSWER-beta-lactam antibiotics 5 generations - each new generation more effective
Carbapenems - ANSWER-class of highly effective antibiotic agents commonly used for the treatment of severe or high-risk bacterial infections
Sulfanomides - ANSWER-Antimetabolic drugs that is a structural analog of para-aminobenzoic acid (PABA) inhibits folate synthesis Prontosil - ANSWER-Dye that contains sulfa molecule; its use began the practice of treating diseases with
drugs
Monobactams - ANSWER-narrow-spectrum drug for infections by gram-negative aerobic bacilli; may be used by people allergic to penicillin
Clavams - ANSWER-needs to be used in combination with another b-lactam because of low efficacy
Glycopeptide antibiotics - ANSWER-non beta lactams; inhibit bacterial cell wall synthesis
Vancomycin - ANSWER-glycopeptide antibiotic used to treat severe but susceptible bacterial infections
Bacitracin - ANSWER-An antibiotic ointment
binds to C-55-isoprenyl pyrophosphate flippase to inhibit cell wall synthesis
Cycolserine - ANSWER-inhibits D-ala-D-ala synthesis
Fosfomycin - ANSWER-Inhibits MurA - enolpyruvate transferase in early cell wall synthesis
Oral treatment of uncomplicated lower UTI's caused by G+ or G- organisms
Trimethoprim - ANSWER--Inhibits bacterial dihydrofolate reductase. Bacteriostatic.
-Used in combination with sulfonamides (trimethoprim-sulfamethoxazole [TMP- SMX]), causing sequential block of folate synthesis.
Cotrimoxazol - ANSWER-trimethoprim + sulfamethoxazole
MoA: inhibits folic acid synthesis
Quinalones - ANSWER-block topoisomerase (DNA gyrase, supercoils)
Rifampin - ANSWER-Binds to the beta subunit of RNA polymerase
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