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Immunology Final Exam – Questions And Answers (A+)
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Immunology Final Exam – Questions And Answers (A+)
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Immunology Final Exam – Questions And Answers (A+)11) Group 1 ILCs are typically activated in response to infections caused by
which of the following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Right Ans - Viruses
11) Group 2 ILCs are typically activated in response to infections caused by
which of the following?
-Extracellular Bacteria
-Viruses
-Helminths
-Fungi
-None of the above Right Ans - Helminths
11) Why are neutrophil transfusions rarely used in treatment of Severe
Combined Neutropenia (SCN)?
-It's difficult to find a matching donor
-The volume of serum needed complicates transfusions
-Neutrophils are short lived and most would die within a day
-The foreign neutrophils could contain intracellular bacteria
-It's more appropriate to use a macrophage transfusion Right Ans -
Neutrophils are short lived and most would die within a day
11) Somatic mutations that truncate the intracytoplasmic tail of what receptor
increase the risk of leukemia?
-G-CSF
-CCFR4
-Fc
-IL-4
-CD40 Right Ans - G-CSF
,11) Resolution of an infection typically involves complete clearance of the
pathogen, and thus the source of antigens, over the course of days to weeks,
following which most effector lymphocytes, which is called:
-Clonal die off
-Clonal disambiguation
-Clonal contraction
-Lymphocyte die off
-None of these Right Ans - Clonal contraction
11) If an individual lacked the ability to mount an innate immune response to
a pathogen, what sort of trend would you expect to see in regards to
microorganism numbers (assuming no medical intervention)?
-Sharp increase, followed by a sharp decrease due to the adaptive immune
response
-A steep and constant increase
-no increase
-slow increase with steady decline
-none of the above Right Ans - A steep and constant increase
11) Approximately how many primary immuno-deficiencies have now been
described that effect the development of immune cells, their function, or both?
- >150
- >50
- >1,000
- >1,500
- <50 Right Ans - >150
11) Which of the following would not be considered a secondary
immunodeficency?
- starvation
- adverse side effects of medical intervention
- inheriting a deficient immune regulatory gene
- all of the above
- none of the above Right Ans - inheriting a deficient immune regulatory
gene
11) Recurrent infection by pyogenic, or pus-forming, bacteria suggests a
defect in antibody, complement, or which cell type?
- cytotoxic T cells
, - Macrophages
- Natural killer cells
- Dendritic cells
- Helper T cells Right Ans - Macrophages
11) If an individual has a history of persistent fungal skin infection, such as
cutaneous candidiasis, or recurrent viral infections suggests a defect in host
defense mediated by what cell type?
- Natural Killer cells
- B cells
- neutrophils
- macrophages
- T-cells Right Ans - T-cells
1) When using FACS (flow cytometry) to determine whether a person has
normal lymphocyte levels, you find there is no fluorescence from the CD3
antibody marker that you used. This would indicate that this person:
-has appropriate numbers of both B and T cells
-Has a B cell deficiency
-Is not producing NK cells
-Has a T cell deficiency
-Is macrophage deficient Right Ans - Has a T cell deficiency
1) The mucosal tissues of the body have their own unique set of immune
structures that function as sites for initiating adaptive immune responses. The
necessity for mucosa-associated lymphoid tissues to have unique cell types (M
cells) and structures is because:
-the mucous layer lining mucosal surfaces makes it difficult for normal APC
function
-The epithelial surfaces that line the gut, lungs and nasal passages inhibit
antigen-presenting cells
-The epithelial cells in mucosal tissues are distinct from those providing skin
barrier function
-Mucosal sites are where most pathogens access the body, and are exposed to
diverse microbes
-Mucosal tissues lack innate sensor cells that can respond to PAMPs Right
Ans - Mucosal sites are where most pathogens access the body, and are
exposed to diverse microbes
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