Endocrinology Exam 2 Questions and Answers
Which method is most often used to measure fractionated catecholamines (epinephrine, norepinephrine, and dopamine)?
A. Measurement of fluorescence following oxidation by potassium ferricyanide
B. Measurement by HPLC with electrochemical detection
...
Which method is most often used to measure fractionated catecholamines (epinephrine,
norepinephrine, and dopamine)?
A. Measurement of fluorescence following oxidation by potassium ferricyanide
B. Measurement by HPLC with electrochemical detection
C. Measure of radioactivity after conversion by catechol-O-methyltransferase (COMT) to
tritiated metanephrines
D. Measurement by HPLC with fluorescence detection - Answer-B
Which statement about sample collection for catecholamines and metabolites is true?
A. Blood for catecholamines is collected in the usual manner following a 12-hour fast
B. Twenty-four-hour urine for vanillylmandelic acid, catecholamines, or metanephrines
is collected in 1 mL of boric acid
C. Twenty-four-hour urine creatinine should be measured with vanillylmandelic acid,
homovanillic acid, or metanephrines
D. There is no need to discontinue medications if a 24-hour urine collection is used -
Answer-C
Which of the following statements applies to both measurement of VMA and
metanephrines in urine? A. Both can be oxidized to vanillin and measured at 360 nm
without interference from dietary compounds B. Both can be measured
immunochemically after hydrolysis and derivatization C. Both require acid hydrolysis
prior to measurement D. Both can be measured by specific HPLC and MS assays -
Answer-D
Urinary HVA is most often assayed to detect:
A. Pheochromocytoma
B. Neuroblastoma
C. Adrenal medullary carcinoma
D. Psychiatric disorders such as manic depression - Answer-B
Thyroid hormones are derived from the amino acid:
A. Phenylalanine
B. Methionine
C. Tyrosine
D. Histidine - Answer-C
Which statement regarding thyroid hormones is true?
A. Circulating levels of T3 and T4 are about equal
, B. T3 is about 10-fold more active than T4
C. The rate of formation of monoiodotyrosine and diiodotyrosine is about equal
D. Most of the T3 present in plasma is from its direct release from thyroid storage sites -
Answer-B
Which of the following statements regarding thyroid hormones is true?
A. Both protein-bound and free T3 and T4 are physiologically active
B. Total T3 and T4 are influenced by the level of thyroxine-binding globulin
C. Variation in thyroxine-binding protein levels affects both free T3 and T4
D. An elevated serum total T4 and T3 is diagnostic of hyperthyroidism - Answer-B
Which of the following conditions will increase total T4 by increasing TBG?
A. Acute illness
B. Anabolic steroid use
C. Nephrotic syndrome
D. Pregnancy or estrogens - Answer-D
Select the most appropriate single screening test for thyroid disease.
A. Free thyroxine index
B. Total T3 assay
C. Total T4
D. TSH assay - Answer-D
Which of the following hormones is often decreased by approximately 25% in the serum
of pregnant women who have a fetus with Down syndrome?
A. Estriol (E3)
B. Human chorionic gonadotropin (hCG)
C. Progesterone
D. Estradiol (E2) - Answer-A
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) causes:
A. Low serum vasopressin
B. Hypernatremia
C. Urine osmolality to be lower than plasma
D. Low serum electrolytes - Answer-D
Select the hormone which when elevated is associated with galactorrhea, pituitary
adenoma, and amenorrhea.
A. E2
B. Progesterone
C. Follicle-stimulating hormone (FSH) D. Prolactin - Answer-D
Zollinger-Ellison (Z-E) syndrome is characterized by great (e.g., 20-fold) elevation of:
A. Gastrin
B. Cholecystokinin
C. Pepsin
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