PCB 3233 EXAM 2
What are the external TLRs - TLR-5:Bacterial Flagellin
TLR-4:Bacterial LPS
TLR-3 recognizes? - Double stranded Viral RNA
TLR-7 recognizes? - Single stranded Viral RNA
TLR-5 recognizes? - bacterial flagellin
TLR-4 recognizes? - Bacterial LPS
Leukocytes in the order to action - 1. Neutrophils - Mass quantities
2. Monocytes
3.Lymphocytes - days later
2 cell type recognition - 1. NK - looking at your own cells
2. Macrophages - looking at pathogen directly
Macrophages - use toll like receptors and phagocytic receptors
PAMP - pathogen associated molecular patterns - on pathogen
PRR - pattern recognition receptors - on leukocyte
Are there different receptor used for phagocytosis vs. cytokine creation and secretion(signalling)? -
yes
,What are the 5 cytokines? - IL-1
TNF-a
IL-6
CXCL8
IL-12
Which cytokines are pyrogens? - IL-1
TNF-a
IL-6
What do heat cytokines (Pyrogens) lead to? - Lead to fever
Which cytokines activate endothelial cells? - IL-1 and TNF-a
What does the activation of endothelial cells lead to? - Vasodilation and Vascular premeability
NK cells provides an early response for which kind of infection? - Viral Infection
NK recognizes two types of receptors - Activating receptors and inhibitory receptors
Activating receptors recognize - (Stress induced) activating ligands which leads to apoptosis.
Inhibitory receptors recognizes - MHC 1 on all nucleated cells.
1st effector cell - Resident Macrophages which is prevalent in connective tissues
CR1 (complement receptor 1) binds to? - C3b
, C3b is degraded by what to become iC3b? - Factor I
NK cells can detect? - MHC molecules
Which receptor can recognize both Gram(-) and Gram(+)? - Scavenger Receptor A (SR-A)
Which leukocyte would be first out to the sight of infection in mass quantities? - Neutrophils
Macrophages Receptors (PRR): - Mannose Receptor
CR-3
CR-4
Dectin-1
SR-A (Scavenger Receptor-A)
SR-B (Scavenger Receptor - B)
LPS (also known as CD14)
TLR
MARCO
Can all nucleated cells use MHC 1? - yes
Macrophages are longlived compared to what? - Neutrophils
Induced innate immune response - -Inflammation
-Leukocytes called into the site of infection
-Soluble molecules made and secreted into the blood and brought to the site of the infection
What can CR1 do for you? - Bind to C3b and phagocytose what ever C3b is bound to
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