science medicine pharmacology overview and medicat
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1. Science
2. Medicine
Pharmacology Overview and Medication
Administration
Terms in this set (90)
Original
Pharmacokinetics
What the body does to the drug as it travels through the body: ADME
Absorption
Distribution
Metabolism
Excretion
It controls the intensity and duration of the drug's action
Absorption
Movement of medication from the site of administration to the bloodstream
IV
IM
SC
Inhalation
Oral
Transdermal
Distribution
Movement of a medication from the bloodstream to the target cells
GI
Liver
Blood!!!!!
Lungs
Metabolism
Breakdown of a drug by the body so it can be eliminated
GI
Liver
Blood!!!!!
Lungs
, Excretion
Removal of drugs and its metabolites from the body
Absorption, Distribution, Metabolism, Excretion
Phase 1: Absorption
Factors affecting absorption
•Solubility (how fast it dissolves)
•GI motility
•Age
•Drug Form
•Drug Route
•Concentration
•Interactions with other substances
Phase 2. Distribution
Factors affection distribution
•Ability of drug to enter/leave capillaries - placenta, blood-brain barrier
Phase 3. Metabolism
Factors affection metabolism
•Age
•First pass effect (↓dose)
•Other diseases
•Polypharmacy
•Increased enzyme production
Phase 3. Metabolism Results
•Drug inactivation
•Promotion of renal excretion - most important
•Changes in therapeutic levels
•Change in toxicity
Phase 4. Excretion
Factors affection excretion
•Age
•Kidney disease
Phase 4. Excretion methods
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