HMX-Pharmacology Questions With Answers Graded A+ Assured Success
11 views 0 purchase
Module
HMX-Pharmacology
Institution
HMX-Pharmacology
bladder - All filtrated by nephrons will be transported through the collecting duct into the renal
pelvis, draining filtrate out of the kidney into the ureter. Next, the filtrate enter the _________ and is
removed from the body
Acetaminophen (Tylenol) - binds to molecular target in the central n...
HMX-Pharmacology
bladder - All filtrated by nephrons will be transported through the collecting duct into the renal
pelvis, draining filtrate out of the kidney into the ureter. Next, the filtrate enter the _________ and is
removed from the body
Acetaminophen (Tylenol) - binds to molecular target in the central nervous system and changes
the way the body senses pain
% molecular response vs concentration - Gradual increase which moves into a due plateau
Receptor occupancy is used to determine molecular response
Taken in a lab setting
This Is called a dose-response curve (DRC)
%Physiological response or % people responding vs dose of drug administered - In a clinical
setting
Gradual increase which moves into a due plateau
This called a drc: linear seal
%Physiological response or % people responding vs dose of drug administered - Plotted on a x log
scale
Can also show concentration of drug at molecular target vs molecular response
x=dose
Semi log plot
In a clinical setting
Curve is more compared and in sigmoidal shape
A range of dose
100% - If administrated intravenously, bioavailability is ___
,1800 - Diabetes=A child was expected to live only past a year after diagnosis
Symptoms found:
Weakness
Excessive urination
Sweet tasting urine
Constant thirst
38L - An adult male has 3L of plasma and ___ of other compartments (inerstitial, intracellular,
transcellular, fat)
38L - Other body compartment including bone, muscle and fat with ____
3L - An adult male has __ of plasma and 38L of other compartments (inerstitial, intracellular,
transcellular, fat)
41L - If Vd is higher than the total ____ body water volume in an average man, Vd is considerably
high
5L - Vascular includes the blood, with a ___
70 kg - The model for pharmacokinetics is male weighing _____
Absorption - as a drug is taken orally and flows through the esaphagus and into the GIT
(gestational tract)
Absorption - The flow of a drug from its site of administration to the bloodstream
Absorption - the movement of drug from the site of administration to the bloodstream
,Absorption - the movement of the site of administration to the bloodstream
Affinity - measure of the strength of drug-receptor bind and is indicated by the equilibrium
dissociation constant, or Kd
age, genetics, weight, sex, health status, and pregnancy - Factors which lead to pharmacokinetic
or pharmodynmics changes between individuals or in an individual over time include
_________________
agonist, antagonist - A drug or endogenous ligand can act act as _______ or an ___________ at a
receptors
Allogenic - T cell are created by patients own cell but engineered to help with any possible disease
presented in the body
anaphylactic shock - Immunological reaction can be immediate, patient goes into _____
Anesthesia - Induction of an awake to unconscious state
Antagonist - Stagnant or straight line
Does Not increase of decrease downward signal(molecular response)
antagonist - zero efficacy
Area under curve (AUC) - On graph, show the total exposure of drug to the body
, Basal - Submaximal
Stagnant or straight line
binding curve - Gradual increase which moves into a plateau due to maximum occupancy
Bioavailability - A large fraction of drug in the system circulation which create a high percentage
Bioavailability - Plasma drug/drug given
bioavailable - the amount of drug that is available in the systemic circulation
Biologics - Biological molecules = _________
Biologics - From natural sources
Growing group of drug modalities
Are less than 20% of the drugs on the market
Larger due to being complex structures
Biologics - Includes vaccines, proteins, antibodies, probiotics, and gene- and cell-based therapies
biotransformation - Through __________, drugs are metabolized into metabolites
blood vessel - If a drug is taken under the tongue, it is moved directly into the _____________ to
bypass the G1 tract. Drugs like nitroglycerin take this path
Blood- brain barriers - are is protection outside the brain have endothelial cell tight pactly
together
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller PatrickKaylian. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £6.37. You're not tied to anything after your purchase.
