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AAB MT HEMATOLOGY EXAM Q&A
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AAB MT HEMATOLOGY EXAM Q&AWhat is hemoglobin composed of?
A. 4 heme, 4 iron, 4 globins
B. 4 heme, 4 iron, 1 globin
C. 2 heme, 2 iron, 2 globins
D. 1 heme, 1 iron, 1 globin - Answer-A. 4 heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to?
A. hemoglobinopathy
B. coagulopathy
C. thalassemia
D. porphyria - Answer-D. porphyria
What is the function of the enzyme methemoglobin-cytochrome C reductase in red
blood cell?
A. to keep iron in the ferric state
B. to keep iron in the ferrous state
C. to maintain an anaerobic pathway for glycolysis
D. to maintain an aerobic pathway for the Krebs cycle - Answer-B. to keep iron in the
ferrous state
Which hemoglobin has a 200 times greater binding capacity for the hemoglobin
molecule than oxygen?
A. carboxyhemoglobin
B. oxyhemoglobin
C. sulfhemoglobin
D. methemoglobin - Answer-A. carboxyhemoglobin
What product is formed when ferrous iron of hemoglobin is oxidized to the ferric state?
A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
D. cyanmethemoglobin - Answer-B. methemoglobin
Which hemoglobin derivative causes irreversible changes in the red blood cells?
A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
,D. cyanmethemoglobin - Answer-A. sulfhemoglobin
Which of the following hemoglobin is NOT normally present in a normal adult?
A. Hb-A1
B. Hb-A
C. Hb-S
D. Hb-F - Answer-C. Hb-S
Which embryonic hemoglobin is normally found in newborns?
A. Hb-F
B. Hb-Gower1
C. Hb-Gower2
D. Hb-Portland - Answer-A. Hb-F
What is the most abundant hemoglobin in a newborn?
A. Hb-Gower
B. Hb-A1
C. Hb-A2
D. Hb-F - Answer-D. Hb-F
What is the molecular structure of hemoglobin S?
A. valine replaces glutamic acid in the 6th position of the beta chain
B. lysine replaces glutamic acid in the 6th position of the beta chain
C. lysine replaces glutamine in the 26th position of the beta chain
D. valine replaces glutamine in the 26th position of the beta chain - Answer-A. valine
replaces glutamic acid in the 6th position of the beta chain
Which of the following hemoglobin is insoluble under lowered oxygen tension?
A. Hb-A
B. Hb-S
C. Hb-C
D. Hb-F - Answer-B. Hb-S
What laboratory test is used to confirm the specific diagnosis of sickle cell anemia?
A. solubility test
B. sodium metabisulfite test
C. hemoglobin electrophoresis
D. presence of sickle cells in the peripheral smear - Answer-C. hemoglobin
electrophoresis
,In the solubility test for hemoglobin S, what is the reagent responsible for the reduction
of the hemoglobin molecule??
A. saponin
B. sodium dithionite
C. sodium hydroxide
D. ammonium sulfate - Answer-B. sodium dithionite
In hemoglobin C, what replace glutamic acid?
A. lysine
B. valine
C. cystine
D. arginine - Answer-A. lysine
Which red blood cell inclusion is characteristic of hemoglobin C disease?
A. Cabot rings
B. Heinz bodies
C. basophilic stippling
D. rod-shaped crystals - Answer-D. rod-shaped crystals
What is hemoglobin F composed of?
A. 2 alpha + 2 epsilon chains
B. 2 alpha + 2 delta chains
C. 2 alpha + 2 gamma chains
D. 2 alpha + 2 beta chains - Answer-C. 2 alpha + 2 gamma chains
Which hemoglobin is resistant to alkali denaturation?
A. Hb-A
B. Hb-F
C. Hb-S
D. Hb-A2 - Answer-B. Hb-F
What hemoglobin are differentiated by the Kleihauer-Betke technique?
A. Hb-A1 from Hb-A
B. Hb-A1 from Hb-F
C. Hb-S from Hb-a1
D. Hb-S from Hb-D - Answer-B. Hb-A1 from Hb-F
What is the order of migration of hemoglobin, from fastest to slowest on cellulose
acetate at pH 8.4?
, A. A1, F, S, C
B. A2, S, F, A1
C. C, S, A, F
D. F, A, S, C - Answer-A. A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are identified on cellulose acetate
at pH 8.6?
A. It separates hemoglobin A from hemoglobin D
B. It separates hemoglobin A from hemoglobin G
C. It separates hemoglobin A from hemoglobin E
D. It separates hemoglobin S from hemoglobin D - Answer-D. It separates hemoglobin
S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin pigments EXCEPT which
one?
A. oxyhemoglobin
B. methemoglobin
C. sulfhemoglobin
D. deoxyhemoglobin - Answer-C. sulfhemoglobin
What is the diluent used in the cyanmethemogloin method for determination of
hemoglobin?
A. 0.1 HCl
B. Pilot's solution
C. Drakbin's solution
D. ammonium sulfate - Answer-C. Drakbin's solution
What is the normal plasma hemoglobin concentration?
A. 2-3 mg/dL
B. 5-10 mg/dL
C. 10-25 mg/dL
D. 25-39 mg/dL - Answer-A. 2-3 mg/dL
Which plasma protein binds free hemoglobin?
A. albumin
B. transferrin
C. hemopexin
D. haptoglobin - Answer-D. haptoglobin
Which one of the following statements concerning hemolytic anemia is false?
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