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Exam (elaborations)

MICR270 TESTED QUESTIONS WITH REVISED ANSWERS UPDATED

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  • Module
  • MICR270
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  • MICR270

MICR270 TESTED QUESTIONS WITH REVISED ANSWERS UPDATED function of antibodies - Answer-neutralization, opsonization, complement activation, effector cell activation basic structure of antibodies - Answer-2 light chains, 2 heavy chains, 1 antigen binding region, 1 FC difference in classes of a...

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  • August 29, 2024
  • 12
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • MICR270
  • MICR270
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MICR270 TESTED QUESTIONS
WITH REVISED ANSWERS
UPDATED

function of antibodies - Answer-neutralization, opsonization, complement activation,
effector cell activation

basic structure of antibodies - Answer-2 light chains, 2 heavy chains, 1 antigen binding
region, 1 FC

difference in classes of antibodies - Answer-heavy chain variation creates different
immune responses

IgM - Answer-first to increase in immune response
Activates compliment
ampliflies inflammatory and adaptive response

IgG - Answer-crosses placenta, most abundant
promotes immune cell recruitment and phagocytosisI

IgA - Answer-mucosal immunity

IgE - Answer-allergic reactions and parasitic infections

IgD - Answer-Attached to B cells

phases of adaptive immune response - Answer-1. Antigen recognition
2. Lymphocyte activation
3. Antigen elimination
4. Contraction (homeostasis)
5. Memory

antigen presenting cells - Answer-dendritic cells, macrophages, B cellsa

antigen processing pathways - Answer-endogenous (MHC1)
exogenous (MHC2)

steps of exogenous antigen processing - Answer-antigen engulfment
proteolytic processing
formation of MHC complex

, cell surface expression
TCR binds to MHC

B cell receptor - Answer-bind directly to free antigens and made of signal itams

T cell receptor - Answer-recognize and bind to MHC w CD8 or CD4

types of cytokines - Answer-interleukins, interferons, growth factors, tumor necrosis
factor, chemokines

Steps of B cell activation - Answer-1. MHC II binds toBCR
2. TCR binds to MHCII
3. Expression of costimulatory molecules
4. Costimulatory signalling
5. helper t cell releases cytokines
6.B-cell differentation

Immune synapse structure - Answer-dSMAC pSMAC cSMAC

immune synapse function - Answer-t-cell activation
holds signal proteins together to make right amount
regulating lymphocyte activation
reorganizing t cell structure to regulate cytokine direction

Chemokines - Answer-induce chemotaxis to promote phagocytosis and wound healing

Interleukins - Answer-regulate immune and inflammatory response

Interferons - Answer-Antiviral proteins secreted by T cells

Tumor necrosis factor (TNF) - Answer-Secreted by macrophages and T cells to kill
tumor cells and regulate immune responses and inflammation

growth factors - Answer-Regulatory proteins that ensure that the events of cell division
occur in the proper sequence and at the correct rate.

major signals in t cell dependant b cell activation - Answer-TCR-petide:MHC II complex
Costimulation
cytokines

primary immunodeficiency - Answer-congenital; usually genetic errors

secondary immunodeficiency - Answer-loss of immune functioning as a result of an
illness or treatment

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