prodrugs - ANSWER- only become pharmaceutically active once they are metabolized within the cell,
and therefore exact mechanism of action is not always entirely clear
attachment antagonists - ANSWER- pleconaril
pleconaril - ANSWER- prevents attachment, exposure of RNA in picornaviruses
enterovi...
Exam 3 Microbiology 2024-2025
prodrugs - ANSWER- only become pharmaceutically active once they are metabolized within the cell,
and therefore exact mechanism of action is not always entirely clear
attachment antagonists - ANSWER- pleconaril
pleconaril - ANSWER- prevents attachment, exposure of RNA in picornaviruses
enterovirus, rhinovirus, Hep A, and poliovirus
entry inhibitors - ANSWER- enfuvirtid
enfuvirtid - ANSWER- binds to gp41 and inhibits HIV membrane fusion
uncoating inhibitors - ANSWER- Amantadine and Rimantadine, Arildone
amantadine and rimantadine - ANSWER- Interfere with Influenza virus protein M2 and prevent
physiological changes needed to result in viral uncoating
arildone - ANSWER- Binds to a stabilizes the Poliovirus capsid, preventing the uncoating, also effective
against HSV-2
acyclovir, valaciclovir, ganciclovir, and penciclovir - ANSWER- converted intracellularly by viral thymidine
kinase, effective against EBV, CMV, HSV, and VZV
, adenosine arabinoside - ANSWER- converted intracellularly by cellular kinases, effective against HSV and
VZV
sofosbuvir - ANSWER- NS5B inhibitor in HCV that prevents viral RNA replication
ribavirin - ANSWER- RNA analog that binds and prevents RNA synthesis in Hantavirus, HCV, and RSV
nucleoside analog reverse transcriptase inhibitors - ANSWER- nucleoside analogs that prevent DNA
synthesis via reverse transcriptase
azidothymidine/Zidovudine - ANSWER- effective against HIV
entecavir - ANSWER- effective against HBV
lamivudine - ANSWER- effective against both HIV and HBV
adefovir - ANSWER- effective against HBV and HSV
protein synthesis inhibitors - ANSWER- fomivirsen, darunavir and fosamprenavir, boceprevir and
telaprevir
fomivirsen - ANSWER- Antisense nucleic acids that bind to mRNA and prevent translation in
Cytomegalovirus
darunavir and fosamprenavir - ANSWER- Protease inhibitors specific to enzymes in HIV that prevent
formation of mature viral proteins
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller BrainEdge. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £10.60. You're not tied to anything after your purchase.
