Exam (elaborations)
NURSE 5334 TEST 1
Exam of 25 pages for the course NURS 5334 at NURS 5334 (NURSE 5334 TEST 1)
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3 NURS 5334 Final Exam Study Guide Latest Version .pdf
1. Exam (elaborations) - Nurse 5334 test 1
2. Exam (elaborations) - Nurse 5334 test 1
3. Exam (elaborations) - Adv pharm uta 5334 exam 1
4. Exam (elaborations) - Nurs 5334 adv. pharmacotherapeutics, final review
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NURSE 5334 TEST 1
Whatcarecthecfourcphasescofcpharmacokinetics?c-c-
cAbsorption,cdistribution,cmetabolism,cexcretion
Bioavailabilityc-cThecextentcofcdrugcthatcbecomescavailablectocthecbodycaftercabsorption
"FreecDrug"c-c-cThecdrugcthatciscnotcboundctocproteincthatciscfreectocexertcactherapeuticceffect
Nicotinecisca?cWhatc(3)ceffectscdoescitchave?c-c-cAcCYPc450cinducerc
-cIncreasecmetabolismcofcdrugcandcresultcincdecreasedceffectscandcshortenedchalf-life
GrapefruitcJuicecisca?cWhatc(3)ceffectscdoescitchave?c-c-cAcCYPc450cInhibitor
-cDecreasedcmetabolismc
-cDrugctoxicityc
-cShortedchalfclife
Kidneysc-cThecmaincorganscresponsiblecforcdrugcexcretion
Half-lifec-cThectimecrequiredcforconechalfcofcthecdrugctocbecremovedcfromcthecbody
PeakcEffectc-cThectimectakencforcthecdrugctocreachcmaximumctherapeuticcresponse
PeakcLevelc-c-cThechighestcconcentrationcofcdrugcincblood
DrugcPolymorphismc-
cTheceffectcofcacpatient'scage,cgender,csize,cbodyccompositioncandcotherccharacteristicsconc
thecpharmacokineticscofcacspecificcdrug
DrugcPolymorphismccancbeccategorizedcintocwhatc(3)cdifferentcfactors.c-
c1.cEnvironmentalc(dietc&cnutritionalcstatus)c
2.cCulturalc
3.cGeneticcfactors
Howccanchigh-fatcdietscaffectcabsorption?cHowccancmalnutritioncaffectcabsorption?c-c-
cHighcFatcDietsc=cincreasedcabsorptioncofcmanycdrugsc
-cMalnutritionc=caltercthecabilityctocabsorbcorceliminatecmedication
DrugsclikecHeroincandcLSDcarecconsideredccategoryc____?c-c-cCategorycI
Thecnormalcrangecforcalbumincisc_____c-c_____cgrams/dLc-c-c4-6cgrams/dl
,IfcthecgastriccpHclevelcischigh,cthiscmeanscthecstomachciscmorec_______cthancnormal.c-c-
cAlkaline
Prodrugc-c-
cAcdrugcthatciscconvertedcfromcancinactivecformcintocancactivecmetabolitecthroughcbiotransfo
rmationcincthecliver
ParadoxicalcReactionc-c-
cThecoppositecreactioncthancwhatciscexpectedcwithcthecspecificcdrug
ThecthreecnamescforcMedications?c-c-cChemical,ctradecandcgeneric
Chemicalcnamecofcacdrugcreferscto?c-c-cThecchemicalcstructure
Tradecnamec/cbrandcnamecofcacmedicationc-c-cproprietarycname
-cmorecexpensivecthancgenericc
-cShorter,ceasiercname
GenericcMedicationc-c-cMostccommonlycusedc
-cmostcprescriptionscare
PharmacokineticscofcOralcMedicationsc(4csteps)c-c1.cDrugciscingestedc
2.cDisintegratedc
3.cFormscacdissolutionc
4.cAbsorptionccancoccur
Whatciscabsorption?c-c-
cThecmovementcofcacdrugcfromcitscsitecofcadministrationcintocthecbloodstreamcforcdistributio
nsctoctissues
Acdrugcthatciscabsorbedcthroughcthecintestinescmustc______cpasscthroughcthec_______cbef
orecitcreachescthec________ccirculation.c-c-
cAcdrugcthatciscabsorbedcthroughcthecintestinescmustcfirstcpasscthroughctheclivercbeforecitcre
achescthecsystemicccirculation
Highcfirst-passceffectc-c-cAclargecportionciscchangedcintocancinactivecmetabolite
Whichcroutescofcmedicationcadministrationcwouldcbecimpactedcbycfirstcpassceffect?c-c-
cAnythingcGIcrelatedccanchavecfirstcpassceffectc
-cOralcandcRectalcadministration
Whichcroutescwillcnotcbecimpactedcbycfirst-passceffect?c-c-cParenteralcandctopical
Whatcarecthec(3)cbasiccroutescofcmedicationcadministration?c-c-
cEnteral,cParenteral,candctopical
, Whatciscenteralcroutecofcmedicationcadministration?c-c-cIscabsorbedcthroughcthecGIcmucosa
Whatciscparenteralcroutecofcmedicationcadministration?cWhatcdoescitcnormallycrefercto?c-c-
cThecfastestcroutec
-cAnycroutecothercthancthecGIctractc
-cNormallycrefersctocinjectionc
-
Wouldcthecdosecofcmedicationcforcancoralctabletcbecthecsamecascintravenouscinjectioncofcthe
csamecmedication?cWhycorcWhycNot?cWhichcwillchavecaclargercdose?c-c-cNoc
-cThecintravenouscroutecbypassescthecliverc
-cThecoralcdosecwillcbecmuchclarger
IfcthecdrugchascachighcfirstcpasscratecwouldcyoucgivecthecsamecdosecIVcascyoucdidcPO?
cWhycorcwhycnot?c-c-cNo
-cYoucwouldcwantctocgivecacsmallercdosecIV
Whatciscthectopicalcroute?cExamples?c-c-cApplicationcofcmedicinectocbodycsurfacesc
-cEx:cOintments,cgelscandccreams
Whatciscthectransdermalcroutecofcmedication?cWhatciscitcusedcfor?cDrugcabsorptioncrate?
cHowclongccancitclast?c-c-cmedicationcdeliverycthroughcadhesivecpatchesc
-cUsedcforcsystemicceffectc
-cConstantcratecofcdrugcabsorptionc
-cOnecpatchccanclastc1-7cdays
Inhalationciscwhichctypecofcroute?c-c-cTopical
(5)cthingscthatccancimpactcabsorption?c(basiccnotcdefinitionsctoo)c-c-cBloodcflowc
-cFoodc
-cTemperaturecofcfoodc
-cGastriccpHc
-cInteractionscofcmedications
Howccancbloodcflowcimpactcabsorption?c-c-
cBloodcflowctocthecGIctractccancbecdecreasedcincthecoldcandcverycyoungcorcindividualscwithcs
hock
Howccancfoodcimpactcabsorption?c-c-cDelaycabsorptioncandcbinding
Howccancfoodctemperaturecimpactcabsorption?cEffectcofcHotc&cCold?c-c-
cHotcfoodsc=cvasodilationcwhichccancincreasecabsorptioncofcmedicationsc
-cColdcfoodsc=ccanccausecvasoconstrictioncwhichccancdelaycthecabsorptioncofcmedication