Hemostasis
termination of bleeding
Two arms of hemostasis
Platelet plug formation
Coagulation cascade
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Platelet Plug
*Primary response to bleeding
*a coll...
Nurs 5315: Adv Patho
Exam 2 Set 2 fully
solved & updated
2024-2025
Hemostasis - answer termination of bleeding
Two arms of hemostasis - answer Platelet plug formation
Coagulation cascade
Platelet Plug - answer *Primary response to bleeding
*a collection of platelets at the site of a damaged blood vessel that
helps slow or stop blood loss
Platelet Structure - answer Disc-shaped cells
1. peripheral zone: outer portion of the cell - cell membrane - made
of phospholipids
2. sol-gel zone: middle layer - contains structural support for the
cell
3. organelle zone - innermost layer - contains organelles
Four phases of platelet plug formation - answer Activation: injury--
>vWF, fibronectin, collagen, thrombospondin--> collagen activates
platelets--> platelets change shape to adhere to injury
,Adherence: platelets attach to injured endothelium-->vWF binds to
collagen and to the GP 1b/IX/V receptors on circulating platelets-->
anchors platelets in place
Aggregation: platelets bind to one another
Secretion: platelet granules release contents
Platelet plug is stabilized by fibrin and XIIIa which are end products
of the coagulation cascade
Normal WBC count - answer 5,000-10,000/mm3
Normal RBC count - answer Male: 4.7-6.1
Female: 4.2-5.4
Normal HgB - answer Men 14-18g/100mL
Females 12-16g/100mL
Normal Hct values - answer Male: 42-52%
Female: 37-47%
Normal MCV range - answer 80-100 cubic micrometers
Normal platelet count - answer 150,000-400,000/mm3
coagulation cascade - answer Secondary Hemostasis
The series of steps beginning with the intrinsic or extrinsic
pathways of coagulation and proceeding through the formation of a
fibrin clot to stabilize the platelet plug
extrinsic pathway of coagulation - answer initial coagulation
pathway that begins with tissue damage > Tissue Factor TF
, activates factor VII > results in the activation of the common
pathway
Intrinsic pathway of coagulation - answer Happens in blood vessels
when collagen fibers of the basement membrane are exposed to
blood
prothrombin - answer Factor II
With prothrombinase complex converted to thrombin
Thrombin - answer converts fibrinogen to fibrin
Fibrinogen - answer with thrombin converts to fibrin
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