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PHCY 401 - ADME EXAM STUDY GUIDE @ 2024
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PHCY 401 - ADME EXAM STUDYGUIDE @ 2024
pharmacokinetics - Answer study of movement of drugs in body
absorption - Answer movement of drug from application site to blood stream
distribution - Answer movement of drug from blood stream to target
metabolism - Answer transformation, activation, detox of drug by enzyme
excretion - Answer elimination of drug from body
hydrophilic - Answer water loving
lipophilic - Answer lipid loving
hydrophobic - Answer water fearing
lipophobic - Answer lipid fearing
logP - Answer partition coefficietn
active transport - Answer energy expended during transport
passive diffusion - Answer no energy during transport
aqueous diffusion - Answer paracellular
through gaps between cells
driven by conc gradient
lipid diffusion - Answer determined by lipid to aqueous coefficient
active/facilitated transport - Answer isnt depended on conc gradient
molecules too large or insoluble to pass
endo/exocyctosis - Answer move large molecules by creating vesicles using cell memb
physiochemical factors affecting memb permeability - Answer MW
lipophilicity
polar surface area
what properities do molecules have to be physiochemically favorable to pass the memb
, - Answer small
lipophilic
unionized
properity of memb to allow passage of molecules - Answer leakiness
if a molecule has low h2o solubility -- it has ____ lipophilicity allowing passage across
memb - Answer high
leaky membranes transport are _______ of lipophilicty, charge, and molecular size -
Answer independent
well knit membrane transport is _____ by lipophilicty, charge, and molecular size -
Answer affected
tight knit memb transport is _______ ________ on lipophilicity, charge, and molecular size
- Answer highly dependent
2 main active transporter families - Answer ATP binding cassette (ABC)
solute carrier (SLC)
ATP binding cassette (ABC) - Answer ATP hydrolysis
efflux
p-glycoprotein
multidrug resistance proteins (MRP)
solute carriers (SLC) - Answer facilitative / secondary active transporter
influx
routes of administration by level of absorption - Answer IV
inhalation
IM
oral
dermal
physiologic factors influencing drug absorption (4) - Answer blood flow
gastric emptying
transit times
pH
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