100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
CMB2004 Questions and Answer | Latest Update 2024/2025 £11.02   Add to cart

Exam (elaborations)

CMB2004 Questions and Answer | Latest Update 2024/2025

 3 views  0 purchase
  • Module
  • Cmb2004
  • Institution
  • Cmb2004

What is the specific/adaptive immunity? ~~> induced by exposure to an infection, very specific and has memory Describe the receptors in the specific immune response ~~> clonaly distributed, a large repitoire at a low frequency What is clonal selection? ~~> during development, cells re...

[Show more]

Preview 4 out of 69  pages

  • September 15, 2024
  • 69
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • Cmb2004
  • Cmb2004
avatar-seller
1 | P a g e | © copyright 2024/2025 | Grade A+




CMB2004 Questions and Answer |
Latest Update 2024/2025
What is the specific/adaptive immunity?


~~> induced by exposure to an infection, very specific and has memory




Describe the receptors in the specific immune response


~~> clonaly distributed, a large repitoire at a low frequency




What is clonal selection?


~~> during development, cells recognising self material are destroyed

leaving only those recognising non-self




Whats the role of clonal selection?


~~> reduces the repertoire leaving a pool of mature naive lymphocytes

which can proliferate and differentiate on activation to form effector cells




What are TCRs?


~~> T cell receptors, expressed by T cells and are always membrane bound




Master01 | September, 2024/2025 | Latest update

, 2 | P a g e | © copyright 2024/2025 | Grade A+


What do TCRs recognise?


~~> processed peptides on MHC on APC




What is this?


~~> TCR complex




What are the four domains of a TCR?


~~> heterodimer of alpha and beta




What can the four domains of a TCR sometimes be?


~~> gamma and delta




Whats CDR?


~~> complementary determining region




How many CDRs does a TCR have?


~~> each chain has 3 so 6 in total




Whats an MHC?




Master01 | September, 2024/2025 | Latest update

, 3 | P a g e | © copyright 2024/2025 | Grade A+


~~> essential for the acquired immune system to recognize foreign

molecules




What does MHC stand for?


~~> major histocompatibility complex




Whats different between MHCI and MHCII


~~> different structures and expression patterns presenting peptides from

different sources




How was MHC first discovered?


~~> in transplant rejection




Which cells are MHCI present on?


~~> all nucleated cells




What are the types of MHCI?


~~> HLA-A/B/C




What domains is the MHCI made of?



Master01 | September, 2024/2025 | Latest update

, 4 | P a g e | © copyright 2024/2025 | Grade A+


~~> alpha 1 2 3 and beta2 microglobulin




In MHCI, which domains are Ig-like?


~~> alpha 3 and beta2 micro globulin




In MHCI, which domains are polymorphic/peptide binding?


~~> alpha 1 and 2




What does MHCI bind with?


~~> CD8+ cells




Which cells are MHCII present on?


~~> APC/cytokine active cells




What are the types of MHCII?


~~> HLA-DQ/DR/DP




What domains is the MHCII made of?


~~> alpha 1/2 and beta 1/2




Master01 | September, 2024/2025 | Latest update

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller ExamArsenal. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £11.02. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

79223 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£11.02
  • (0)
  Add to cart