AAB MT HEMATOLOGY REVIEW QUESTIONS WITH VERIFIED SOLUTIONS.
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Module
AAB MT HEMATOLOGY
Institution
AAB MT HEMATOLOGY
What is hemoglobin composed of? - CORRECT ANSWER 4 heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to? - CORRECT ANSWER Porphyria
Porphyria - CORRECT ANSWER Deficiency in the enzymes of the porphyrin pathway leads to insufficient production ...
AAB MT HEMATOLOGY REVIEW 2024-2025
QUESTIONS WITH VERIFIED SOLUTIONS.
What is hemoglobin composed of? - CORRECT ANSWER 4 heme, 4 iron, 4
globins
What disorder does a defect in heme synthesis lead to? - CORRECT ANSWER
Porphyria
Porphyria - CORRECT ANSWER Deficiency in the enzymes of the porphyrin
pathway leads to insufficient production of heme. The principal problem in these
deficiencies is the accumulation of porphyrins, the heme precursors, which are
toxic to tissue in high concentrations.
What is methemoglobin? - CORRECT ANSWER Methemoglobin is a form of
hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind
oxygen. However, the ferric iron has an increased affinity for bound oxygen. When
methemoglobin concentration is elevated in red blood cells, tissue hypoxia can
occur.
What is the function of the enzyme methemoglobin-cytochrome C reductase in a
red blood cell? - CORRECT ANSWER To keep iron in the ferrous state
What product is formed when ferrous iron of hemoglobin is oxidized to the ferric
state? - CORRECT ANSWER Methemoglobin
,AAB MT HEMATOLOGY REVIEW 2024-2025
QUESTIONS WITH VERIFIED SOLUTIONS.
What is carboxyhemoglobin? - CORRECT ANSWER A stable complex of carbon
monoxide and hemoglobin that forms in RBCs when carbon monoxide is inhaled or
produced in normal metabolism. Large quantities of it hinder delivery of O2 to the
body. Tobacco smoking (through carbon monoxide inhalation) raises the blood
levels of COHb by a factor of several times from its normal concentrations.
Which hemoglobin has a 200 times greater binding capacity for the hemoglobin
molecule than oxygen? - CORRECT ANSWER Carboxyhemoglobin
Which hemoglobin derivative causes irreversible changes in RBCs? - CORRECT
ANSWER Sulfhemoglobin -- makes blood incapable of carrying oxygen.
Which of the following hemoglobins is NOT normally present in a normal adult? -
CORRECT ANSWER Hb-S
Which embryonic hemoglobin is normally found in newborns? - CORRECT
ANSWER Hb-F
What is the most abundant hemoglobin in a newborn? - CORRECT ANSWER
Hb-F
What is the molecular structure of Hemoglobin S? - CORRECT ANSWER Valine
replaces glutamic acid in the 6th position of the beta chain
,AAB MT HEMATOLOGY REVIEW 2024-2025
QUESTIONS WITH VERIFIED SOLUTIONS.
Which of the following hemoglobins is insoluble under lowered oxygen tension? -
CORRECT ANSWER Hb-S
What laboratory test is used to confirm the specific diagnosis of sickle cell anemia?
- CORRECT ANSWER Hemoglobin electrophoresis
In the solubility test for hemoglobin S, what is the reagent responsible for the
reduction of the hemoglobin molecule? - CORRECT ANSWER Sodium dithionite
In hemoglobin C, what replaces glutamic acid? - CORRECT ANSWER Lysine
Which red blood cell inclusion is characteristic of hemoglobin C disease? -
CORRECT ANSWER Rod-shaped crystals
What is hemoglobin F composed of? - CORRECT ANSWER 2 alpha and 2
gamma chains
Which hemoglobin is resistant to alkali denaturation? - CORRECT ANSWER
Hb-F
Which hemoglobins are differentiated by the Kleihauer-Betke technique? -
CORRECT ANSWER Hb-A1 from Hb-F
, AAB MT HEMATOLOGY REVIEW 2024-2025
QUESTIONS WITH VERIFIED SOLUTIONS.
What is the order of migration of hemoglobins, from fastest to slowest, on
cellulose acetate at pH 8.4? - CORRECT ANSWER A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are identified on cellulose
acetate at pH 8.6? - CORRECT ANSWER It separates hemoglobin S from
hemoglobin D
The cyanmethemoglobin method measures all hemoglobin pigments EXCEPT which
one? - CORRECT ANSWER Sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method for the determination
of hemoglobin? - CORRECT ANSWER Drabkin's solution
What is the normal plasma hemoglobin concentration? - CORRECT ANSWER
2-3 mg/dL
Which plasma protein binds free hemoglobin? - CORRECT ANSWER
Haptoglobin
Which one of the following statements concerning hemolytic anemia is false? -
CORRECT ANSWER The serum haptoglobin is increased
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