SBB Chapter 7 Other Blood Groups Exam 2024 Update
Lutheran antigen biochemistry. - ANSWER-antigens are located on a membrane glycoprotein
Lutheran antigen frequencies - ANSWER-Lua rare. Lub 92%. Lu(a+b+) 8%. Lu(a-b-) rare.
Lutheran antigen function - ANSWER-weakly expressed on cord cells. May be...
Lutheran antigen function - ✔✔✔ANSWER-weakly expressed on cord cells. May
be linked to adhesion properties and the mediation of intracellular signaling.
,Lutheran antigens - ✔✔✔ANSWER-LuA and LuB
Lutheran genetics - ✔✔✔ANSWER-The LU locus is on chromosome 19 and is
linked to the Se (secretor) locus. The H, Le, and LW genetic loci are also on
chromosome 19. It contains alleles LUA and LUB. Lu(a-b-) or Lunull occurs with
a person is homozygous for the rare LU recessive amorph allele, or when a
dominant inhibitor gene In(Lu) is inherited (not at the LU locus), or when an X-
linked suppressor gene is inherited in a recessive manner as Lumod phenotype.
McLeod syndrome - ✔✔✔ANSWER-In addition to red cell abnormalities due to
lack of Kx antigens, they may have muscular and neurologic defects. The X-linked
disorder of chronic granulomatous disease (phagocytic WBCs impaired, so patient
susceptible to infection) is occasionally associated with McLeod syndrome due to
genetic deletion of both loci on the X chromosome.
MNS - ✔✔✔ANSWER-M, N, S, s, U
MNS antibodies - ✔✔✔ANSWER-M and N not significant, IgM, RT/37/AHG,
destroyed by enzymes, exhibit dosage. S and s significant, IgG, 37/AHG, variable
affected by enzymes, exhibit dosage. U is significant, IgG, and reacts with all S+ or
s+ red cells. U negative cells are found only in blacks.
51Cr labeled red cell studies - ✔✔✔ANSWER-the traditional method to determine
clinical significance where radiolabeled antigen-positive cells are transfused
slowly and tested for remaining radioactivity.
Alloanti-PP1PK or anti-Tja - ✔✔✔ANSWER-Found in P, P1, PK negative (little
p) individuals. Naturally occurring. Potent hemolysins - clinically significant.
, amphipathic - ✔✔✔ANSWER-having both a hydrophilic region and a
hydrophobic region such as the phospholipid bilayer of a red cell membrane with
hydrophilic heads and hydrophobic tails
Anti-Ku - ✔✔✔ANSWER-Anti-Ku (anti-Kell Universal) is directed against all
cells with any Kell antigens and is produced by K0 individuals. Anti-KL, anti-Kx
and anti-Km react with normal Kell antigen expressions. Anti-KL = anti-Kx + anti-
Km.
Anti-Nf - ✔✔✔ANSWER-Often found in dialysis patients exposed to
formaldehyde-sterilized dialyzer membranes.
Antibody-Dependent Cellular Cytotoxicity (ADCC - ✔✔✔ANSWER-measures
lysis of antibody coated cell in a chemiluminescence assay which is useful for
HDFN risk.
Autoanti-P - ✔✔✔ANSWER-Associated with PCH (paroxysmal cold
hemoglobinuria).
Carbohydrates of the red cell membrane - ✔✔✔ANSWER-make up antigens and
are 8% of the RBC membrane. Found on the outer surface only. They are carried
on glycosphinolipids-cerimides. The carbohydrate coat on the red cell membrane is
called the glycocalyx.
Cartwright - ✔✔✔ANSWER-antigens Yta (high), Ytb. Destroyed by DTT.
Chido/Rogers - ✔✔✔ANSWER-Ch, Rg. (both high) Destroyed by enzymes. Have
HTLA characteristics.
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