PMCOL 343: Asthma Exam Questions With Correct Answers
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Module
PMCOL 343
Institution
PMCOL 343
PMCOL 343: Asthma Exam Questions With
Correct Answers
What is asthma characterized by - answerInflammation of the airways, bronchial hyper
reactivity, reversible airway obstruction
What is the immediate phase of asthma - answerBronchospasm; the initial response to
allergen, promoting the relea...
PMCOL 343: Asthma Exam Questions With
Correct Answers
What is asthma characterized by - answer✔Inflammation of the airways, bronchial hyper
reactivity, reversible airway obstruction
What is the immediate phase of asthma - answer✔Bronchospasm; the initial response to
allergen, promoting the release of inflammatory mediators from mast cells and the release of
chemotaxins, which attract leukocytes to the site
What is the late phase of asthma - answer✔Inflammation; inflammatory cells release mediators
that cause damage to epithelium
What are eosinophils - answer✔Inflammatory cells (type of leukocyte)
What is the mechanism of action for beta agonists in treating asthma (3) - answer✔Dilate the
bronchi, allowing for easier air passage, increase mucus clearance, as well as inhibit mediators
released from mast cells
What type of bronchodilators are salbutamol and terbutaline - answer✔Short acting beta-2
agonists (3-5 hrs)
What type of bronchodilators are salmeterol and formoterol - answer✔Long acting beta-2
agonists (8-12 hrs)
What are the 3 main adverse effects of beta-2 agonists - answer✔Tachycardia (B2 in heart
increase heart contraction), dysrhythmias, and tremors (B2 in skeletal muscle)
What is the mechanism of action for drugs theophylline / aminophylline -
answer✔Methylxanthine based agent, inhibits phosphodiesterase
How would inhibiting PDE help asthma symptoms - answer✔Decreases degradation of cAMP,
promoting higher PKA levels, reducing intracellular calcium levels, leading to bronchodilation
What group of enzymes is responsible for metabolizing theophylline / aminophylline -
answer✔CYP450 enzymes (drugs not prescribed for people on drugs that inhibit CYP450)
Describe the therapeutic window for theophylline / aminophylline - answer✔Narrow window
of 30 - 100 microns, with adverse effects common in > 110 microns
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