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OCCTH 585 - Alzheimer's Disease Questions and Answers 100% Solved
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OCCTH 585 - Alzheimer's Disease Questions and Answers 100% Solved
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OCCTH 585 - Alzheimer's Disease Questions andAnswers 100% Solved
Density of Plaques Correct Ans-- Temporal lobe is most severely affected
- Hippocampus volume is reduced by up to 60% in advanced AD
- Reduced connectivity of the hippocampus with other brain regions
β-amyloid plaques Correct Ans-Defective breakdown of a benign substance known as
amyloid precursor protein (APP)
Produce sticky, insoluble shards of β-amyloid plaques
- stick together, form dense plaques, damage axons, lead to development of neurofibrillary
tangles
Neurofibrillary Tangles Correct Ans-Normally tau serves as connectors for a track like
structure in the cell body of every neuron for transporting nutrients
Tau somehow becomes hyperphosphorylated, destroy nutrient supply destroying neuron,
axon, dendrites, synapses
, OCCTH 585 - Alzheimer's Disease Questions and
Answers 100% Solved
(Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of
neurofibrillary degeneration)
Neural systems for AD Correct Ans-Limbic System:
- Impacts our behaviout
- Plays a role in basic instincts such as sleping and eating
- Plays a role in emotions
- impacts sense of smell
- The hippocampus, which is part of the limbic system, is important for learning and short
term memory - the part of the brain where short-term memories are converted to long-term
memory for storage - also where verbal and visual memory are processed
Circadian rhythms are affected (day-night cycle)
Suprachiasmatic necleus within the hypothalamus (circadian clock)
, OCCTH 585 - Alzheimer's Disease Questions and
Answers 100% Solved
Neurotransmitter abnormalities Correct Ans-Tracks form by cholinergic neurons
(containing acetylcholine) are destroyed
Nucleus basalis has projections to cortical areas, volume reduce by ~70% in AD
Brain Atrophy Correct Ans-Severe shrinking of the entire cortex
Severely enlarged ventricles
Severe shrinkage of hippocampus
Rate of neuronal loss accelerates as the disease progresses
Whole brain weight decreased by 10% to 19%
Not evenly distributed
Mostly in gyri of association areas
Relatively less: primary motor, primary somatosensory and primary visual cortices
-- Mostly the medial temporal lobe is affected --
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