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Summary First year pharmacy at Newcastle university notes: Medicinal Chemistry £4.99   Add to cart
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Summary First year pharmacy at Newcastle university notes: Medicinal Chemistry

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First-year medicinal chemistry notes that break down drug structures and chemical properties in an easy-to-understand way. Great for mastering key concepts and getting ready for exams!

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  • September 24, 2024
  • 15
  • 2022/2023
  • Summary

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hinders nucleophile
a p p ro a c h

Speds up Sun as
it stabilises carbocation
-
Steric hinderance




&
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pi orbitals can m a ke

racemic ste rcon
e
# Possible



wineo
must b e i n molecule nucleophilic electrons always m ove
towards electrophile




·
correct
geometry
↑
↑
neutralor-ve Donates




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Carbocation forms
in ↑ - e l e c t ro n

rate
determing step
.

(SN1) Identifyind nucleophiles


↑
Y h ave


nonbonding
↑ cone
pairs




SNc Nucleophiles Electrophiles
have ↓
empty
and
atomic

SM
als o anions

and Orbital
or With
antibanding
Ips .




↑ Orbita

Reactions Carbon Skeleton
↳ neutral or
-




↑
+ve
↳ - ↓
d SW does not
dependy secondary tertiary Identifying Electrophies
,
SN2 depends ↓
nucleophi le +
on on

electrophile
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leaving group
good electrophiles have
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