Initiation stage - ANSWER: Direct exposure of DNA to carcinogen resulting in
irreversible changes that will permit malignant transformation
Promotion stage - ANSWER: Occurs when the initiated cell is exposed to an agent
that encourages or enhances cell growth
Progression stage - ANSWER: Characterized by a series of changes in the
transformed cell, including accelerated growth rate, enhanced invasiveness, and
altered appearance and biochemical activity
Metastasis stage - ANSWER: The ability of transformed cells to relocate from their
original population by direct extension, invasion, and/or establishment of remote
sites. Tumor develops a blood supply
Non-modifiable risk factors - ANSWER: Age
Race
Hereditary
Sex
Cancer prevention - ANSWER: Aimed at measures to ensure that the cancer never
develops
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