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PCOL Exam Questions With Correct Answers

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PCOL Exam Questions With Correct Answers Drug Y will have a lower therapeutic effect - answerA patient is on maintenance medication with Drug X, an enzyme inducer. Later, Drug Y was added to his therapeutic regimen. Which of the following would be expected? A. Drug X will decrease the Vd of Dr...

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  • October 20, 2024
  • 17
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • PCOL
  • PCOL
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©SIRJOEL EXAM SOLUTIONS
12/3/2024 11:27AM



PCOL Exam Questions With Correct
Answers


Drug Y will have a lower therapeutic effect - answer✔A patient is on maintenance medication

with Drug X, an enzyme inducer. Later, Drug Y was added to his therapeutic regimen. Which of

the following would be expected?




A. Drug X will decrease the Vd of Drug Y

B. Drug Y will have a longer t1/2

C. Drug X will increase the protein binding of Drug Y

D. Drug Y will have a lower therapeutic effect E. None of these


Pharmacodynamics - answer✔A branch of pharmacology that deals with the study of the effects

of drugs in the body


Pharmacokinetics - answer✔body to drug


toxicology - answer✔study of toxic effects of drugs


psology - answer✔study of doses

, ©SIRJOEL EXAM SOLUTIONS
12/3/2024 11:27AM


inducer - answer✔increase metabolism, fast excretion of drugs, LOWER half-life, lower

therapeutic efffect


inhibitor - answer✔decrease metabolism, slow to none excretion, HIGHER half life, higher

therapeutic effect BUT TOXIC


Typical Antipsychotic - answer✔act on DOPAMINERGIC system; blocks dopamine type 2

receptors


Atypical Antipsychotic - answer✔act on SEROTONERGIC; particularly in 5-HT2A (serotonin);

lower affinity for dopaminergic receptors


TRAP - answer✔Parkinsons symptoms


Chlorpropamide - answer✔Sulfonylurea with longest half-life; risk of hypoglycemia


N-acetyltransferase - answer✔metabolism of HIPS is dependent on this phase II enzyme


Acetylation - answer✔HIPS are metabolized through


Alpha 2 - answer✔adrenergic receptor exerts its action via inhibition of cAMP production thru

inhibition of adenylyl cyclase activity


Gs - answer✔stimulates


Gi - answer✔inhibits adenylate cyclase; inhibit conversion of ATP to cAMP

, ©SIRJOEL EXAM SOLUTIONS
12/3/2024 11:27AM


Gq - answer✔increased IP3 and DAG (q as qontraction)


Nn & Nm - answer✔ligand-gated Na channels


Hemicholinium - answer✔inhibit reuptake of choline NOT storage


Vesamicol - answer✔drug that acts on VESICULAR STORAGE of ACH


Sumatriptan - answer✔serotonin agonists is best prescribed to relieve the symptoms of migraine


Triptans (5-HT B/D) - answer✔Migraine


Buspirone (5-HT 1A) - answer✔smoking cessationl partial agonist anxiolytic; decreases 5HT

release in CNS


Tegaserod (5-HT4) - answer✔for Irritable Bowel Syndrome


Ondansetron (5-HT3) - answer✔nausea and vomiting (chemo px)


M1 selective inhibitor (Piperazine) - answer✔tx for Peptic Ulcer Disease


myasthenia gravis - answer✔NEOstigmine & PHYSOstigmine


glaucoma - answer✔a physostigmine


alzheimer's - answer✔donepezil; RIVAstigmine; galantamine


A2 selective antagonists - answer✔guanFACINE; guanABENZ; clonidine

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