Growth Hormone
• Growth hormone is also known as
somatotropin.
• It is a peptide hormone that stimulates
growth, cell production and cell regeneration.
• It is secreted by the anterior lobe of the
pituitary gland
September 20, 2022 Growth hormone 3
Structure
• Human growth hor...
,• Growth hormone is also known as
somatotropin.
• It is a peptide hormone that stimulates
growth, cell production and cell regeneration.
• It is secreted by the anterior lobe of the
pituitary gland
, Structure
• Human growth hormone
– Has 191 AA residues
– MW 22000 (22K hGH)
• GH is bound to a protein in plasma
– ½ Of GH activity is bound which form
• Reservoir of hormone to
• Compensate for wide fluctuation in secretion
September 20, 2022 Growth hormone 3
, Structure
• GH is metabolized rapidly
– Probably in the liver
• The ½ life of circulating GH in human
– 6 to 20 minutes
• The daily GH output
– Is about 0.2 – 1.0 mg/d in adults
September 20, 2022 Growth hormone 4
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