100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
DNA DAMAGE AND REPAIR £7.16   Add to cart
Quickly navigate to
Preview
  2.  
  3. University Of East Anglia
  4.  
  5. CANCER BIOLOGY

Lecture notes

DNA DAMAGE AND REPAIR
 3 views  0 purchase

* DNA Repair & Cancer * Cancer & Genomic Instability * Sources of DNA Damage * Types of DNA Damage * DNA Repair Pathways * Defects on DNA Repair & Links with Human Disease * MMR & HNPCC * DNA Damage & Apoptosis * P53 * Cancer Therapy and DNA Damage * BRCA1 & BRCA2 and PARP * POLY-ADP-RIB...

[Show more]

Preview 2 out of 6  pages

Document information

  • October 29, 2024
  • 6
  • 2022/2023
  • Lecture notes
  • Dr helen james
  • All classes

Subjects

Written for

All documents for this subject (2)

Seller

avatar-seller
biologicalscientistgal

Content preview

L10: DNA DAMAGE & REPAIR [17/10/2022]



I. DNA REPAIR & CANCER

 Each cell is thought to undergo >20,000 DNA damaging events and >10,000 replication
errors per day
 What is the connection between DNA repair and cancer?
 Genomic instability:
 It is linked with human cancers
 Problems with DNA repair led to genome instability



II. CANCER & GENOMIC INSTABILITY

 Cancer cells show genomic instability:
 Subtle sequence changes – cause mutations
 Dramatic karyotypic changes – gains and losses of complete or partial chromosomes,
chromosome rearrangements

 In some cases, still trying to determine what is cause and effect.
 Does genome instability cause cancer?
 Do cancerous cells have greater genome instability?



III. TYPES OF DNA DAMAGE:

, IV. MAJOR SOURCES OF DNA DAMAGE




V. MAJOR TYPES OF DNA REPAIR

 Various DNA repair pathways have evolved to maintain genomic stability
- Excision repair
 Base excision repair (BER)
 Nucleotide excision repair (NER)

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller biologicalscientistgal. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £7.16. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

75632 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£7.16
  • (0)
  Add to cart