MCPHS - PHARMACOLOGY EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
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Module
MCPHS
Institution
MCPHS
MCPHS - PHARMACOLOGY EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
Pharmacodynamics
The effects of the drugs on the body
Receptor
A molecule to which a drug binds to bring about a change in function of the biologic system
Receptor site
Specific region of the receptor molecule...
A molecule to which a drug binds to bring about a change in function of the biologic system
Receptor site
Specific region of the receptor molecule to which the drug binds
Inert binding molecule or site
A molecule to which a drug may bind without changing any function
Spare receptor
Receptor that does not bind drug when the drug concentration is sufficient to produce max elect
Effector
Component that accomplishes the biologic effect after the receptor is activated by an agonist (e.g.
Channel or enzyme molecule)
Efficacy, maximal efficacy (Emax)
The maximum effect that can be achieved with a particular drug, regardless of dose
, Potency
The amount of drug needed to produce a given effect
EC50
The Concentration that causes 50% of the maximum effect or toxicity
ED50
The Dose that causes 50% of the maximum effect or toxicity
TD50 (TC50)
The median toxic Dose (or concentration), the dose (concentration) at which toxicity occurs in 50% of
cases
LD50 (LC50)
The median Lethal Dose (or concentration), the dose (concentration) required to kill half the members of
a tested population
Kd
The concentration of drug that binds 50% of the receptors in the system
Bmax
Maximal number of receptors bound
Agonist
A drug that activates its receptors upon binding
Partial Agonist
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