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PHMY 610 EXAM 1 ADAPTIVE IMMUNE RESPONSE {FANG} TEST QUESTIONS AND ANSWERS
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PHMY 610 EXAM 1 ADAPTIVE IMMUNE RESPONSE {FANG} TEST QUESTIONS AND ANSWERS...
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PHMY 610 EXAM 1 ADAPTIVE IMMUNERESPONSE {FANG} TEST QUESTIONS
AND ANSWERS
what is a molecule that could be recognised by lymphocytes or antibodies?
antigen
what are antigens that are capable of inducing an immune response in the host
organism?
immunogens
what are the cells that capture microbial antigens and display them for
recognition by T lymphocytes?
antigen presenting cells
-
what are the kinds of APCs?
professional: dendritic cells, macrophages, B cells
non-professional: all nucleated cells
what are the functions of APCs?
- present peptides for recognition by T cells; first signal
- express second signal for T cell activation
APCs express major ________ ________ ________ molecules.
major histocompatibility complex
, what are membrane proteins expressed on APCs and display peptide antigens
for recognition by T lymphocytes?
MHC molecules
where are MHC molecules found?
mammals
human MHC proteins are called what? what do they do?
human leukocyte antigens
they cause rejection after transplantation
MHC locus contains two types of polymorphic genes, what are they?
class I and class II
which cells are considered class I MHC molecules?
non-professional: all nucleated cells (APCs)
which cells are considered class II MHC molecules?
professional APCs: dendritic cells, macrophages, B cells
MHC locus contains many nonpolymorphic genes, what class are they?
class III
what is MHC restriction?
T lymphocytes of a specific individual can see peptides only when these
peptides are display by that individuals MHC molecules
which cells are present in tissues in contact with the external environment and
microbes that breach the epithelial barriers and enter the body are captured
by these?
dendritic cells
what are properties of MHC genes?
- highly polymorphic
- codominantly express
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