PNCB Exam test preparation Questions and Must have marking scheme Updated version 2024/2025
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PNCB
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PNCB
PNCB Exam test preparation Questions and Must have marking scheme Updated version 2024/2025
If you suspect anemia, what labs should you order? (from professor) - correct answer 1. CBC
2. Reticulocyte count
What lab value indicates whether the bone marrow is responding/correcting the anemia ...
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PNCB Exam test preparation Questions and
Must have marking scheme Updated version
2024/2025
If you suspect anemia, what labs should you order? (from
professor) - correct answer 1. CBC
2. Reticulocyte count
What lab value indicates whether the bone marrow is
responding/correcting the anemia caused by bone marrow
failure, hemorrhage or hemolysis?
What lab value ensures the bone marrow is responding
appropriately to given therapy? - correct answer reticulocyte
count / reticulocyte prodcution index
What lab value ensures the bone marrow is responding
appropriately to given therapy? - correct answer reticulocyte
count / reticulocyte prodcution index
Reticulocyte production index:
-definition
-importance of value - correct answer definition:
-a calculation to more accurately reflect the reticulocyte
production in the diagnosis of anemia because the absolute rbc
count decreases in anemia
Importance of value:
,-indicates whether the bone marrow is responding and corrects
for the degree of anemia
-tells you how well they are responding to therapy
-*index of bone marrow health and response to anemias*
*a. (anemia due to:
1. Bone marrow failure
2. Hemorrhage or hemolysis)*
*b. Response to therapy*
-low level: <2 (reflects decreased or ineffective bone marrow
production of reticulocytes for the degree of anemia)
-high level: >3 (if bone marrow failure or blood loss causes
anemia, the body compensates by making more rbcs, thus
increasing reticulocyte count)
1. Hemolysis
2. Blood loss
3. Sickle cell
-sickle cell: chronic hemolytic (breaking down rbc)
,-normal rbc lives 120 days / sickle cells lives 10 days
-body makes new - as body responds will see absolute rbc count
decrease
Total iron binding capacity (tibc) - correct answer ability /
capacity to take in iron
Ferritin (my notes)
-definition
-importance / function
-lab values
1. Increased / indicates (1)
2. Decreased / indicates (1) - correct answer -iron storage
protein, soluble in blood, reflects storage in the bone marrow
-importance/function:
-ferritin's role: 'acute phase' protein in the inflammatory
response and hepatic damage in patients with advanced disease.
Lab values:
-increased: (reflect an increase in body iron stores)
1. Repeated transfusions (can cause heart, liver and endocrine
problems;iron chelation: necessary to treat hyperferric state if
>300, >400 or >1000mcg)
-low: (used/goes down before serum ferritin)
, 1. Ida (serum ferritin <30)
Anemias
-definition
-characterized by: - correct answer -conditions caused by
various disorders of rbc count, qualtiy of hbg and/or volume of
packed rbcs
-classification:
1. Classified according to rbc size (mcv)
2. Classified according to hemoglobin concentration (mchc)
Causes of anemia of chronic disease (acd)? - correct answer -
renal failure
-chronic renal insufficiency
What are the normocytic/normochromic anemias in peds? (3) -
correct answer 1. Acd - anemia of chronic disease (renal failure,
chronic renal insufficiency)
2. Acute blood loss
3. Early ida
What are the microcytic/hypochromic anemias in peds? (4) -
correct answer 1. Ida
2. Thalassemia
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