Antidepressants that should be avoided in patients taking CYP 450 metabolized drugs. -
ANSWER Paroxetine and Fluoxetine (inhibits CYP2D6)
(T/F) Postpartum patients with postpartum depression can take antidepressants when
breastfeeding - ANSWER True
(T/F)SRRI used in third trimester has bene linked to persistent pulmonary HTN of
newborn - ANSWER True
Which medications are FDA-approved for the tx of mania in patients with bipolar
disorder? -ANSWER Lithium, Chlorpromazine, Divalproex, and Antipsychotics
(Olanzapine, and Risperidone)
Which medications are FDA-approved for the tx of patients with bipolar depression?
-ANSWER Quetiapine, Lurasidone, and Olanzapine/Fluoxetine
What features need to be present to support a Dx of MDD with atypical features?
-ANSWER There needs to be the presence of marked mood reactivity (improvement of
mood in response to actual/potential positive events) and 2 or more: weight gain,
increased appetite, hypersomnia, leaden paralysis, and a long standing pattern of
interpersonal rejection sensitivity.
Best drugs in a MDD patient who wishes to stop smoking. -ANSWER Bupropion
(Wellbutrin) and Nortriptyline (Pamelor)
Best drugs in a Parkinson's patient with MDD. - ANS SNRIs (Venlafaxine, duloxetine, or
desvenlafaxine) and noradrenergic agents (desipramine)
,Effects of serotonin syndrome - ANS Hyperthermia, HTN, tachycardia, and tachypnea.
Dilated Pupils, hyperreflexia and clonus.
Effects of NMS - ANS Hyperthermia, HTN, tachycardia, and tachypnea. Diaphoresis,
sialorrhea, "Lead Pipe" rigidity, reduced reflexes.
Treat MDD for at least _________ with antidepressants - ANS 6 months
ANS: In older patients with anorexia and insomnia take _______for MDD - ANSWER
Mirtazapine (has sedative and weight gain effects)
Antidepressant to lose weight and stop smokin? - ANSWER Bupropion (Wellbutrin)
Which antidepressant class has the potential to increase osteoporosis in geriatric
patients - ANSWER All SSRIs.
SSRIs increase the risk of suicide in what patients? - ANSWER children, adolescent,
young adults
Which of the following cardiac arrhythmias is associated with Citalopram - ANSWER
Prolonged QT and Torsades du Pointes
Which of the following are medications to be avoided in pts with BPH and MDD? -
ANSWER Trazodone, TCA, and MAO inhibitors
Which ethnicity is at highest risk of MDD in USA? - ANSWER Native Americans
Does MDD affect platelet activation? - ANSWER Yup, can increase it.
Is MDD more a diagnosis of younger or older populations? - ANSWER Younger
, In patients with untreated MDD, which population has a higher risk of suicide: younger
or older? ANSWER Older
Which of the following is an endocrinopathy associated with diabetes mellitus? (Mark all
that are true.)
Cushing's syndrome
Acromegaly
Pheochromocytoma
Gastrinoma
Glucagonoma - ANSWER Acromegaly, Cushing's syndrome, glucagonoma, and
pheochromocytoma.
Hyperthyroidism
PT HAS:hepatomegaly and mild testicular atrophy.
AST (SGOT).260
ALT (SGPT).210 U/L (N 10-55)
TOW - ANSWER Hemochromatosis
Classic clinical features include
=
bronze skin pigmentation,
+
diabetes mellitus,
+ hepatomegaly with hepatic dysfunction,
+
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