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PHM 431 Exam Questions and Answers
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PHM 431 Exam Questions and Answers
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PHM 431 Exam Questions and AnswersYou have trained rats to press a bar in a cage in order to receive food pellets. Prior to
conducting your experiment, the rats are food-deprived so that they are motivated to
perform the bar pressing task. One group of hungry rats presses the bar very frequently
while a second group of hungry rats does not press the bar frequently. One explanation
for these data is that the second group of rats: - Answer-Has been treated with an NPY
receptor antagonist
Amphetamines suppress appetite. The brain area that mediates this effect is the: -
Answer-hypothalamus
Which of the following drugs is not a substrate for the vesicular monoamine transporter?
- Answer-methylphenidate
Although MDMA is an amphetamine-like drug, it has pharmacological properties that
differ from amphetamine. The major difference between amphetamine and MDMA is: -
Answer-MDMA, but not amphetamine, is a preferred substrate for SERT
Amphetamine is a false neurotransmitter because: - Answer-It is a substrate for VMAT
but it is not an agonist at dopamine receptors
Which of the following is an enzyme found in the liver that is responsible for degradation
of catecholamines found in the diet and absorbed from the small intestine? - Answer-
Catechol-O-methyl transferase
Local injection of which of the following drugs into the ventral tegmental area of a
laboratory rat would reduce the rewarding effects of cocaine? - Answer-CNQX, an
AMPA receptor antagonist
Cocaine is an unusual drug because laboratory rats develop long lasting sensitization to
the psychostimulant effects of cocaine after repeated cocaine treatments. Which of the
following treatments would block this behavioral sensitization? - Answer-Knockout of the
gene encoding brain derived neurotrophic factor
Hyperthermia is a toxicity caused by recreational use of which of the following drugs? -
Answer-3,4-Methylene-dioxymethamphetamine
A unique feature of chronic cocaine use is sensitization (rather than tolerance) to
cocaine's effects. A "knockout" of which of the following genes in a laboroatory mouse
would reduce behavioral sensitization to the effects of repeated cocaine administration.
- Answer-deltaFosB
The principal target for the addictive actions of cocaine is: - Answer-The dopamine
transporter in the nulceus accumbens
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