Exam (elaborations)
PHM 431 Exam 1 Questions and Answers
- Module
- Institution
PHM 431 Exam 1 Questions and Answers
[Show more]
Seller
Follow
lectknancy
Reviews received
Content preview
PHM 431 Exam 1 Questions andAnswers
Describe drug tolerance - Answer-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for
example)
What is a drug that could easily cross the blood brain barrier? - Answer-Hydrophobic
drug (molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? -
Answer-A non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug
is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape
of Drug A but is further right on the graph. What does this mean? - Answer-Drug A is a
full agonist; Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - Answer-Chemical antagonism
(drug interacts with another chemical to inactivate drug or make it inaccessible to site of
action)
Many factors affect risk for drug addiction. What factor would NOT increase risk that an
individual will become addicted to a drug? - Answer-High level of plasma protein binding
(Would increase are: high BBB permeability, release of DA in NAc, and rapid onset of
drug action)
Figure with drug naive curve on left and drug experienced curve further right shows
what pharmacodynamic principle? - Answer-Drug tolerance
Drug A is furthest left and middle height. Drug B is in the middle and has lowest height.
Drug C is furthest right and has highest height. What does this signify? - Answer-Drug C
is the lowest potency, highest efficacy agonist (X axis position determines potency, Y
axis determines efficacy/response size)
What term belongs with myelin sheath and Node of Ranvier? - Answer-Saltatory
conduction (APs jump node to node)
Activation of what type of ion channel is responsible for the rising phase of an AP? -
Answer-Sodium channel
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller lectknancy. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £8.52. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75759 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now