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GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
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GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED What is the relationship between oncogenes and proto-oncogenes? Proto-oncogenes become oncogenes during carcinogenesis Which form(s) of oncogene activation involve(s) a mechanism that will NEVERdirectly change the DNA sequence...

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  • November 23, 2024
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  • 2024/2025
  • Exam (elaborations)
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GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE

SOLUTIONS VERIFIED


What is the relationship between oncogenes and proto-oncogenes?

Proto-oncogenes become oncogenes during carcinogenesis

Which form(s) of oncogene activation involve(s) a mechanism that will

NEVERdirectly change the DNA sequence in a cell? Choose all that apply.

Hypomethylation

Does the presence of oncogenes make it harder or easier to develop selective

anti-cancer agents with fewer side effects?

Easier

What is the relationship between Ras and Myc mutations in cancer?

Myc mutations increase the lethality of Ras inhibitors.

What is the effect of one cycle of the sodium potassium pump in cells?

3 sodium ions out, 2 potassium ions in

The resting membrane potential of a neuron is _____.

-90 mV

If you are measuring the voltage across a cell membrane and place one electrode

just outside of the membrane, in which location should you place the other

electrode in order to measure the greatest voltage difference?

Intracellularly, near the membrane

, What is the relationship between conductance across a membrane and the

number of channels that are open in that membrane?

Conductance is proportional to the number of receptors

Which single-channel patch clamp technique mimics a scenario where the void of

the needle serves as the "inside" of the cell and the solution the tip of the needle

is placed into serves as the "outside?"

Outside out recording

What is the mechanism by which voltage-gated channels open in response to

voltage changes?

Charged residues in the channel lead to a conformation change

The voltage-clamp technique is uniquely able to keep which variable constant?

(Em - Erev)

Two neurons show the same current flow upon activation in response to the

same stimulus. If neuron A has channels that stay open longer, which situation

would explain how the two neurons achieve equal current?

Neuron B has more channels

Though which mechanism is glutamate signaling stopped?

Re-uptake of glutamate

Hyperpolarization following an action potential induced by ACh administration is

primarily caused by activation of which receptors?

mAChR

Which ion channels may serve as pharmacological targets for treating epilepsy?

Voltage-gated channels, GABA receptors, Glutamate receptors, Calcium channels

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