- increase plasma osmolarity, decrease water reabsorption in PCT
sacubitril target
- angiotensin receptor neprilysin
sacubitril mechanism
- inhibit breakdown of ANP, BNP, Bradykinin and Adrenomedullin
- increased vasodilatory, diuretic, and natriuretic effects
acetazolamide target
carbonic anhydrase
acetazolamide mechanism
- directly inhibits reabsorption of HCO3-
- indirectly inhibits reabsorption of Na+
heparin target
antithrombin III
heparin mechanism
- activates antithrombin III to inhibits factor Xa
- immediate anticoagulation
LMHW target
antithrombin III
LMWH mechanism
- activates antithrombin III to inhibit thrombin, factor IXa, Xa, XIa
- immediate anticoagulation
amicar target
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