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BIOL 4100 EXAM 2 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++
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BIOL 4100 EXAM 2 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ makes use of membrane bound protein complexes to directly move specific proteins from one compartment to a topographically different compartment transmembrane transport name the mitochondrial subcompartment: -have cristae...

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  • December 3, 2024
  • 41
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • biol 4100 exam 2 questions and answers with comple

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BIOL 4100 EXAM 2 QUESTIONS AND ANSWERS WITH COMPLETE

SOLUTIONS GRADED A++

makes use of membrane bound protein complexes to directly move specific

proteins from one compartment to a topographically different compartment

transmembrane transport

name the mitochondrial subcompartment:

-have cristae invaginations

-only protein, no complexes, no pores

-only allows active transport

inner mitochondrial membrane

name the mitochondrial subcompartment:

-lipid bilayer

-has pores and protein complexes

outer mitochondrial membrane

name the mitochondrial subcompartment:

-topographically similar to cytoplasm because of pores

intermembrane space

name the mitochondrial subcompartment:

-location of mitochondrial DNA

mitochondrial matrix

T/F: the mitochondrial matrix and the intermembrane space are topographically

similar

,F

name the mitochondrial subcompartment:

-invaginations in the inner mitochondrial membrane

cristae

where is the mitochondrial localization signal located on the ribosome after

translation? what are MLS used for? what do they bind to?

first 20 peptides (at N terminus) that come out of ribosome after translation, used for

proteins that come off ribosome and are not free in the cytoplasm, chaperones

mitochondrial localization signals

-__________ proteins

-positively charged _____________ alpha helix

-directs precursor proteins to the ______ or _______ of the mitochondria

-usually cleaved from the _______ upon maturation in the mitochondrial

compartment

precursor, amphipathic, inner membrane or matrix, maturation

describe the test that found that Beta barrel proteins are targeted to mitochondria

by a dedicated beta hairpin element

YFP (protein with a hairpin bond, also shows fluorescence) was cleaved and half was

bound to TOM, when the other half of the protein with the hairpin was allowed close to

the mitochondrial membrane, fluorescence was seen

T/F: though it is common for alpha helices to be present at the N terminus of

MLSs, it is not required for functionality

T

,describe the process for chaperones for mitochondrially targeted proteins

preprotein acts with cytosol chaperones (normally HSP70 family); preprotein/chaperone

leave MLS available to interact with TOM receptor as they move through the cytoplasm;

general import port (inside of TOM) uses ATP to allow MLS to start feeding preprotein

though

why do the TOM proteins not allow much folding in a protein trying to feed

through them?

the pore is very small

what are the 3 common mitochondrial translocation complexes? what are their 3

main functions?

TOM, TIM23, TIM22; receptor recognition, channel conductance, force for vectorial

movement

how many times can channel conductance occur?

2

what are the Tom proteins involved in the TOM complex? where does translocase

with TOM take place?

Tom40, 22, 5,6,7, 70, 20; outer membrane (into mitochondria)

name the TOM complex protein:

-channel forming protein and main component of the TOM complex of the OMM

essential for import of protein precursor

-form quaternary structure once 3 of these have come together

Tom40

, name the TOM complex protein:

-functions as the transit peptide receptor of the TOM complex, accepting

precursor proteins from the TOM70 and TOM20 receptors

TOM22

name the 3 TOM complex protein:

-regulate the assembly and stability of the TOM complex

TOM5,6,7

name the TOM complex protein:

-receptor responsible for the recognition and translocation of chaperone assisted

precursor proteins through the TOM complex of the OMM

-preproteins without MLS; chaperones have MLS

TOM70

name the TOM complex protein:

-receptor responsible for the recognition and translocation of presequence

containing proteins through the TOM complex of the OMM

-preproteins have LMS

TOM20

what are the TIM proteins involved in the TIM23 complex? where does

translocase with TIM23 take place?

Tim23, 17, 44, Ssc1p, Yge1p, Tim50; inner mitochondrial membrane

name the 2 TIM23 complex protein:

-essential component of the TIM23 complex, that mediates the translocation of

presequence containing proteins across the IMM

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