THROMBOSIS - PATHOLOGY AND
PHARMACOLOGY
• Evaluate the differences in pathology between arterial and venous thrombosis •
Discuss how anti-platelet drugs work • Discuss how the different anticoagulants work •
Discuss how fibrinolytics work
THROMBOSIS
• The term thrombophilia is used to describe inherited or acquired disorders of
haemostatic mechanisms which predispose to thrombosis
• thrombosis is thje pathological formation of a haemostatic plug within the
vasculature
• clinically this can result in ischemia from local vascular occlusion of distant
embolization (a procedure that uses particles to block a blood vessel)
• thrombi can form in arteries and veins
• arterial thrombosis can lead to myocardial infaction or stroke
• venous thrombosis often presents as deep vein thrombosis (DVT) or pulmonary
embolism (PE)
, ARTERIAL THROMBOSIS
• Arterial thrombosis is a major cause of mortality and morbidity worldwide.
• • Ischemic heart disease accounted for ~ 7 million deaths (2015)
• • Put simply, arterial thrombosis is a blood clot that develops in an artery.
• • Arterial thrombosis typically forms under high shear conditions and are “platelet
rich” in a fibrin mesh (socalled white thrombus)
• • Often associated with atherosclerosis
◦ • ‘Atherothrombosis’
• • Can lead to MI or stroke
RISK FACTORS
• • Positive family history • Previous MI or stroke • Hyperlipidaemia • Hypertension •
Diabetes mellitus • Smoking • Polycythaemia
CAUSES OF ATHEROTHROMBOSIS
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