Pharmacology: Chapter 8 Lehne Exam 2025 with 100% correct answers
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Pharmacology: Chapter 8 Lehn
Institution
Pharmacology: Chapter 8 Lehn
Major factors in which drug responses in individuals can vary - correct answers Body weight and composition
Age
Pathophysiology
Tolerance
Placebo effect
Variability in absorption
Genetics and pharmacogenomics
Gender and race related variations
Comorbidities and drug interactions
Diet
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Pharmacology: Chapter 8 Lehne Exam
2025 with 100% correct answers
Major factors in which drug responses in individuals can vary - correct answers ✔✔Body weight and
composition
Age
Pathophysiology
Tolerance
Placebo effect
Variability in absorption
Genetics and pharmacogenomics
Gender and race related variations
Comorbidities and drug interactions
Diet
Failure to take medicine as prescribed
Body weight and composition - correct answers ✔✔Intensity of the response to a drug is determined in
large part by the concentration of the drug at its sites of action - higher the concentration, more intense
the response is.
Importance of body composition - correct answers ✔✔Sometimes, body surface area is more important
than weight.
Infants heightened drug sensitivity - correct answers ✔✔result of organ immaturity
other factors that affect sensitivity in older patients - correct answers ✔✔increased severity of illness
presence of multiple comorbidities
treatment with multiple drugs
, Older adults heightened drug sensitivity results largely from - correct answers ✔✔decline in organ
function
Four pathologic conditions impacting drug response - correct answers ✔✔kidney disease
Liver disease
acid-base imbalance
Altered electrocyte status
Kidney disease - correct answers ✔✔reduces drug excretion, causing accumulation in the body which
can result in toxic levels of accumulation.
Liver disease - correct answers ✔✔drugs cannot metabolize, resulting in accumulation of drugs that can
reach toxic levels.
Acid-base imbalance - correct answers ✔✔Results in alters in absorption, distribution, metabolism and
excretion of drugs due to pH paritioning
Altered electrolyte status - correct answers ✔✔disrupts multiple cellular processes, but does not have a
profound and widespread effect
Tolerance - correct answers ✔✔decreased responsiveness to a drug as a result of repeated drug
administration
Three types of drug tolerances - correct answers ✔✔Pharmacodynamic tolerance
Metabolic tolerance
tachyphylaxis
Pharmacodynamic tolerances - correct answers ✔✔long term administration of drugs results in
adaptation and the minimum effective concentration becomes abnormally high
Metabolic tolerance - correct answers ✔✔tolerance resulting from accelerated drug metabolism, and
does not effect MEC
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