Lecture notes
DNA Errors and Repairs Notes
- Module
- Cells to Systems (M22177)
- Institution
- University Of Portsmouth (UoP)
PDF file containing notes from DNA Errors and Repairs lesson for Biology. Content is for A-level students
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🌻DNA Errors and Repair
Created @January 20, 2025 3:55 PM
Class Cells to Systems
Base pairing rules to be maintained to avoid mistakes leading to genome
mutation
Polymerase proof reads strand for wrong nucleotide, removes it and adds the
right nucleotide
Sex cells not being repaired means inherited diseases can develop, and
regular cells producing cancer
Proofreading
DNA polymerase adds incorrect nucleotide
Mispaired nucleotide is removed by 3’→5’ proofreading
Correctly paired 3’ end allows addition of next nucleotide
Synthesis continues in 5’→ 3’ direction
DNA Repair and Replication
Mismatch Repair
Happens after new DNA is made
Remove and replaces mis-placed pairs
Able to detect and correct insertions/deletions
DNA Errors and Repair 1
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