Lecture notes
Co- Solvents and Solvents Notes
- Institution
- University Of Portsmouth (UoP)
PDF file containing notes from Co- Solvents and Solvents lecture part of Molecules to Medicine module for Pharmacology.
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🦖Co- Solvents and Solvents
Created @January 20, 2025 5:27 PM
Class Molecules to Medicine
Importance of Solubility:
Drug must be soluble in water and lipid based aspects
H bonding and hydrophobic interactions can affect the biological
behaviour of molecules
Water is actively involved in drug transport to the action site, especially if
the drug is administered orally which needs to dissolve in gastric fluid
before transportation
Poor Solubility of Mebendazole:
Almost insoluble in water, 96% is ethanol. Also methylene chloride
Absorption is less than 10% in oral administration due to incomplete
absorption systemically
Used to treat gastrointestinal infestations of threadworm
Bulk Liquids:
Molecules are distributed at random
Frequent collisions
Spaces between molecules provide fluidity
Molecules are held together temporarily by intermolecular forces
Some molecules evaporate
Co- Solvents and Solvents 1
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