Lecture notes
Receptor Signalling Notes
- Institution
- University Of Portsmouth (UoP)
PDF containing notes from the Receptor Signalling lecture for the Principles of Neuroscience and Pharmacology module
[Show more]
Seller
Follow
Content preview
🦀Receptor Signalling
Created @January 21, 2025 12:59 PM
Class Principles to Neuroscience and Pharmacology
Learning Objectives:
Basic principles of Ligand- Receptor Interactions
General principles of G-protein receptors
Basic principles of GPCR and Intracellular Targets
Adenylyl cyclase-cAMP-PKA signalling pathway
Phospholipase C-PIPIP and DAG signalling pathway
GPCR regulation of ion channels
GPCR as drug targets
Basic principles of Ligand- Receptor Interactions
Ligands
Chemicals act on specific receptors to produce a particular response
Specificity
Certain ligands bind to certain receptors that can recognise specific drugs
Agonists
Drug bound to its receptor and mimics its response
Antagonist
Receptor Signalling 1
, Competes with agonists to stop the signal between the agonists and
the receptor
Blocks certain responses
Principles of Signal Transduction:
4 families of receptors
Most endogenous ligands are hydrophilic and are unable to across the cell
membrane
Nuclear Receptors can cross the cell membrane and are activated by
steroid hormones and other lipid soluble signals
Receptors acts as transducers by receiving a signal and transform it into a
different signal type, known as signal transduction
In GPCR- Ligands induce intracellular second messenger release that act
on different signalling pathways
General Principles of G-Protein Receptors:
Big family of cell surface receptors
Contains lots of ligands including neurotransmitters
All ligands have transmembrane domains
Extracellular domain binds to ligand
Intracellular domain binds to G-protein
G-protein binds to guanine nucleotides GDP and GTP
G proteins have subunits Alpha, Beta and Gamma
Subunits bind to GDP, GTP and undergo GTPase activity
Receptor Signalling 2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ricebucket. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £5.96. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
62774 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 15 years now