Lynch syndrome - Study guides, Revision notes & Summaries

WGU D027 Practice Test A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast...

____cancer is the most common gynecological cancer in the US. The MC type is ____followed by mucinous, clear cell, and squamous cell. - ANSWER-Endometrial, Adenocarcinoma Endometrial cancer: The most common route of spread is _____. - ANSWER-via direct extension of tumor downward toward cervix or outward through myometrium and serosa The most common precursor of endometrial cancer is ____. - ANSWER-endometrial hyperplasia Pathology: 80% is Type I and occurs in women with history of chro...

Lesch-Nyhan Syndrome: what causes it and what are manifestations? - ***HGPRT deficiency in purine salvage pathway (this enzyme normally converts hypoxanthine to IMP and guanine to GMP). This deficiency leads to excessive Uric acid production and de novo purine synthesis. It is X linked recessive. Symptoms: hyperuricemia, gout, aggression / self mutilation, mental retardation, dystonia. 2. Treatment for Lesch-Nyhan? - ***Allopurinol / febuxostat second line. Both of these drugs inhibit...

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) - ***AD MLH1, MSH2, MSH6, PMS2 gene mutation causing DNA mismatch repair 3-2-1 rule: cancer in 3 family members, within 2 generations, and in 1 relative under 50 Most common hereditary form of colorectal cancer Associated with gastric, endometrial, ovarian, & urothelial cancer Familial Adenomatous Polyposis (FAP) - ***· Mutation of the APC gene · Hundreds of colonic polyps that arise in childhood · FAP does not predispose to e...

HBOC correct answers breast, ovarian, prostate, melanoma Familial Adenomatous Polyposis correct answers CHRPE (congenital hypertrophy of the retinal pigment epithelium) Li-Fraumini correct answers early breast, sarcoma, brain, leukemia, adrenocortical, choroid plexus tumors (childhood), fam hx childhood onset tumors Cowden correct answers Folliular Thyroid, Breast, uterine, macrocephaly, Lhermitte-Duclose disease (LDD)= cerebellar dysplastic gangliocytoma Cowden correct answers Papil...

AANP - Walden (Women's Health & Pregnancy)/ AANP - Walden (Women's Health & Pregnancy), Walden University. Questions and Correct Answers. Updated 2024. For post menopausal bleeding: DO ULTRASOUND FIRST OR REFER FOR ENDOMETREAL BIOPSY Dominant breast/breast cancer: characteristics and diagnostics mass one side feels hard, irregular, immobile, located tail of spence, skin color peu d orange (resembles orange peel), dimpling retraction, painless, bloody nipple discharge DX: order mammogr...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? - The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. According to the Centers for Disease Control and Prevention, the 10 most costly chronic conditions include cardiovascular diseases, obesity, asthma, diabetes, smoking and alcohol related conditions,...

REFERENCES 1 Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: [PMID: DOI: 10.1002/ijc.25516] 2 American Cancer Society. Global Cancer Facts and Figures. 2nd ed. Atlanta: American Cancer Society, 2011 3 Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 21...

AP Unit 6 Advanced Exam Questions Correctly Answered 2024. Scientists conducted a transformation experiment using E. coli bacteria and the pTru plasmid. Samples of the pTru plasmid (lane A) and the chromosomal DNA from two different E. coli strains that the scientists attempted to transform (lane B and lane C) were compared using gel electrophoresis. The results are shown in Figure 1. - CORRECT ANSWER Which of the following statements best explains the experimental results observed in Figu...

An Ames test of a compound suspected to be a mutagen was examined before and after incubation with rat liver extract. Based on the results shown, what do you conclude? correct answers Compound is mutagenic without liver enzymes and this activity is further enhanced by liver enzymes Lynch syndrome is a human genetic disease characterized by ~100-fold higher incidence of colon cancer in men and women - and uterine cancer in women - by the age 50, as compared to the general population. Which sta...