Gpcr activation - Study guides, Revision notes & Summaries

Why is celecoxib selective for COX-2 inhibition as compared to COX-1 inhibition? COX-1 contains Ile-523, whereas COX-2 contains Val-523, which permits celecoxib binding. COX-1 contains Ile-523, whereas COX-2 contains Val-523, which blocks celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which permits celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which blocks celecoxib binding. COX-2 is located in the endoplasmic reticulum where ...

Which of the following is important for increased neurotransmitter release from the siphon sensory neuron of aplysia in response to sensitization? a. Increased action potential frequency b. Action potential broadening c. None of these d. Increased action potential intensity Action potential broadening 1. Regarding classical conditioning inaplysia, what is the coincidence detector a. Calmodulin b. PKC c. PKA d. Adenylyl cyclase Adenylyl cyclase 1. How does sensitization differ f...

1. Which type of learning results from repeated harmless stimulation of the mantle in Aplysia? a. Long term potentiation b. Sensitization c. Post tetanic potentiation d. Habituation - ️️Habituation 1. Which of the following are important for the activation of protein Kinase A (PKA) a. Gq/11 GPCR b. Phospholipase C (PLC) c. Phosphatidyl serine d. Diacyl glycerol e. All of these f. None of these - ️️None of these 1. Which of the following is important for increased neurotransm...

MCPHS PHARMACOLOGY I FINAL EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE 2024/2025 Drug An exogenous chemical administered to alter biological/physiological process to cure/treat/prevent disease/illness Dissociation Constant (Kd) The smaller the numerical value the greater the affinity a drug has for a given receptor/drug target Transporters Moves substances into a cell Pumps Moves substances out of a cell Ion-Channels (and the two different types) Selective...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

As the Metabolic Syndrome progresses towards overt type 2 diabetes, symptoms typically arise chronologically. Which of the following arrangements best represents the chronological order of their development, from earliest to latest. A. Hyperinsulinemia, insulin resistance, central adiposity, retinopathy. B. Central adiposity, insulin resistance, hyperinsulinemia, retinopathy C. Retinopathy, central adiposity, insulin resistance, hyperinsulinemia D. Insulin resistance, hyperinsulinemia, cen...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

Describe endocrine, paracrine, and autocrine signaling. correct answers Endocrine: An endocrine cell releases a hormone into the blood stream to target a receptor on the target cell. Paracrine: A signaling cell releases a local mediator to target cells (neighboring cells). Autocrine: A cell releases a chemical signal to target itself. How does a hormone that is released generally throughout the body end up having different effects on (or no effects on) different cells? correct answers H...

Receptors and Signaling, Protein Engineering Exam Questions With Verified Answers. What are the five characteristic features of signal transduction? - answer1. Specificity: a given stimulus triggers a specific response 2. Amplification: a small incoming signal causes a cascade that results in a large response 3. Modularity: different components can be mixed and matched to build a signaling pathway 4. Desensitization: the ability to turn a signaling pathway off 5. Integration: the ability...