Pembrolizumab - Study guides, Revision notes & Summaries

ESMO Exam Questions and Answers checkpoint inhibitors --> enhance immune system to kill the cancer cells - Answer-true anti-CTLA-4 drugs - Answer-ipilimumab (tremelimumab) anti-PD-1 drugs - Answer-Nivolumab Pembrolizumab (PDR001) anti-PD-L1 drugs - Answer-atezolimumab durvalumab avelumab tumors with what have better responses to and better survival after PD-(L)1 therapy? - Answer-tumors with IFN-gamma gene profile high level of infiltrative CD8+ T cells true / ...

When PDL1 binds to PD1 inhibits the cytotoxic activity of the T cell - cancer cells have evolved to be able to turn off the body's defense pembrolizumab is going to bin to PD1 so that PDL1 cannot and the T cell is not inhibited nitrosoureA - - alkylating agent very lipid soluble - can cross BBB effective for brain tumors Microtubule DE polymerization inhibitor - - once the microtubules are constructed they also have to be torn down. if they remain intact then the cells get stuck to...

ABSITE Study guide Exam Questions with Key Marking Scheme Updated 2024/2025 The best treatment option for a simple unilocular cystic mass in the mesentery of the small bowel - correct answer enucleation In post-op pts, what % of prescribed opioid pills were not taken - correct answer 72% Chemo drug that is a monoclonal Ab against PD-1 receptors on T cells used in melanoma, bladder cancer, RCC, NSCLC - correct answer Pembrolizumab Chemo drug that is a monoclonal Ab that blocks CTLA-4 ...

Doxorubicin Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin Cardiotoxic (cardiomyopathy) Bleomycin AVOID oxygen supplementation Methotrexate Leukovorin decreases cytotoxicity Pemetrexed Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine Immunosuppression Thioguanine Bone Marrow Suppression Stomatitis/Mucositis 5-FU *Stomati...

Predictors of PDL1/PD1 inhibitor response Presence of tumor CD8 cell infiltration High cancer genome burden High levels of cancer PD-L1 expression (PD1 is on the cytotoxic T cell) Ipilimumab CTLA4 inhibitor Nivolumab PD-1 inhibitor Regorafenib VEGF inhibitor Bevacizumab Monoclonal antibody against VEGF-A. Inhibits angiogenesis. Pembrolizumab PD-1 inhibitor Atezolizumab PD-L1 inhibitor Avelumab PD-L1 inhibitor Durvalumab PD-L1 ...

Predictors of PDL1/PD1 inhibitor response Presence of tumor CD8 cell infiltration High cancer genome burden High levels of cancer PD-L1 expression (PD1 is on the cytotoxic T cell) Ipilimumab CTLA4 inhibitor Nivolumab PD-1 inhibitor Regorafenib VEGF inhibitor Bevacizumab Monoclonal antibody against VEGF-A. Inhibits angiogenesis. Pembrolizumab PD-1 inhibitor Atezolizumab PD-L1 inhibitor Avelumab PD-L1 inhibitor Durvalumab PD-L1 inhibitor Cemiplimab PD-1 inhibitor fo...

melanoma - Stage I or II - CORRECT ANS surgery melanoma - Stage III - CORRECT ANS nivolumab, ipilumumab melanoma - BRAF positive Stage III - CORRECT ANS dabrafenib + trametinib melanoma - BRAF positive Stage IV, aggressive, bulky, symptomatic - CORRECT ANS dabrafenib + trametinib, vemurafenib + cobimetinib melanoma - Unresectable stage III with in-transit lesions - CORRECT ANS Talimogene Laherparepvec (T-VEC) melanoma - Stage IV - CORRECT ANS nivolumab, pembrol...

KU'S OCN REVIEW COURSE WITH COMPLETE SOLUTIONS 100% What disease and drug is this target associated with: BTK (brutin's Tyrosine Kinase) - correct answer Lymphoma/CLL (chronic lymphocytic leukemia) GVHD; Ibrutinib What disease and drug is this target associated with: Cyclin Dependent Kinase (CKD 4/6) - correct answer Breast; ribociclib What disease and drug is this target associated with: poly(ADP-ribose) polymerase (PARP) inhibitor - correct answer recurrent epithelial ovarian, fallo...

Chemotherapy Certification Exam Questions and answers, 100% Accurate. VERIFIED. Doxorubicin - Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin - Cardiotoxic (cardiomyopathy) Bleomycin - AVOID oxygen supplementation Methotrexate - *Leukovorin decreases cytotoxicity* Pemetrexed - Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine - Immunosuppression Thioguanine - Bone Marr...

Immunotherapy / Chemotherapy Exam With 100% Verified And Correct Answers 2024