Cmb2004 - Study guides, Class notes & Summaries

What is a pathogen? ~~> A microorganism that causes disease e.g. bacteria, fungi, virus, parasite For an effective immune response the immune system must... ~~> - be able to recognise and respond to any invading organism - not over react to benign or self - be able to direct different effector mechanisms against different pathogens What is specific/adaptive immunity? ~~> - it is induced by exposure to a particular infection - shows a high degree of specificity - exhib...

Origin of haematopoietic stem cells? ~~> Bone marrow Site of B cell development to the stage of immature B cell? ~~> Bone Marrow what light chain is expressed first? ~~> kappa If BCR expressed by immature B cell binds to self cell surface antigen, the B cell is removed via? ~~> negative selection TF that haematopoeitic cells express leading to B cell development ~~> PAX5 Activated B cells in the periphery can develop into? 2 | P a g e | © copyright 2024/2025 | Grade ...

CMB2004 PRACTICE EXAM ...

CMB2004 TEST LATEST UPDATED...

what does immunological tolerance create ~~> random generation of repertoire of BCR and TCR production of self reactive specificities types of TCR recognition due to random TCR gene rearrangement ~~> - can't recognise self-MHC (die) - recognise self MHC and p from Ag in thymus (+ve then eliminated by -ve selection) - self MHC and p not in thymus (+ve selection) what is TCR survival and tolerance based on ~~> TCR affinity need a pop of cells with medium affinity to self MHC...

CMB2004 (immunity) Exam Questions And Answers 100% Verified. What must an effective immune response do? (4 things) - answerBe able to recognise and respond to invading pathogen Not over-react to to benign or self Be able to direct different effector mechanisms against different pathogens Links innate and adaptive responses What is adaptive immunity? (3 details) - answerIt is induced by exposure to a PARTICULAR infection, it has a high degree of specificity. It exhibits memory What is t...

CMB2004 Exam Questions With Verified Answers. Are B and T lymphocytes part of the adaptive or innate immune response? - answerAdaptive it is the immune memory evolved over time What is the clonal selection theory? - answerImmature lymphocytes that could self find are destroyed Mature naive lymphocytes are mature until they are exposed to antigens What are the two types of B receptor? - answerMembrane bound And released from membrane they are known as antibodies T cell receptors are only...