Cells and Immunity (BI2BC45)

Hallmarks of Cancer/Ageing, Genomic and Metabolic Alterations, Cellular Senescence, Contributions and Advancements of Science

Examples of Models, Principles of 3R's, Transgenics, Oglionucleotide-based approaches.

Migration Steps, The Immune Response

Historical Timeline and Introduction to the Module

Clinical Immunology, Immunepathologies, Defense Mechanisms, Innate and Adaptive Immunity,

Homeostatis, Mechanim of Haematopoiesis, Types of Innate Cells,

Historical Significance of Names such as; Maxwell, Lorentz, Einstein, Heisenberg, Karl Popper, Thomas Kuhn, Imre Lakatos, Feyerabend.

Body Defenses, Response after Recognition

Protein Targeting, Vesicle Trafficking, Secretion, Compartmentalisation, Polarised Cells, Nuclear Pore Complexes, G-Protein Cycles, Clathrin.

Metastasis, Cancer Staging,

Signalling, Production, Mechanism of Action, Cancer,

Harvey McMahon Theory, Ras MAP Pathway, Protein Kinase Families, Molecular Switches,

PI3-Kinase, Lipid Binding Domains, Regulation of fork head localisation, Signalling Growth.

Protein Production, Turnover, Degredation, Post translational modifications, Breakdown of misfolded proteins, mTOR switch