Lecture notes
Bioscience
- Module
- Medicine (A100)
- Institution
- Keele University (KU)
This covers basic DNA structure and DNA replication stages
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BioscienceNucleolus :
Nuclear envelope : Nuclear pores : Nucleoplusm
-
Outer membrane
-
out - mRNA -
Nucleolus :
-
Chromatin :
in nude tides ☐ RNA synthesis
Innermembrane
-
-
-
☐ , ,,swne,
0 Subunits (proteins )
ODNAA
-
✗
Ribosomes
µ
☐
Heterochromatin
FEET
☐
- nuclear pore
#
chromatin -
highly condensed
-
nutranscriph.vn
"" "
☐ Euchromatin
nucleoplasm -
loose chromatin
-
transcription
nuclear o cell replication -
chromosomes
envelope
⇐ÉÉ É:÷
☐ Octamer
✗
• 1- -
H2A , H2B , -113,11-4 (✗2) proteins
phosphodiester bond
✗
(
'
✗
'
5 -3 +
Histone o
lysine toe charge
:*
.
backbone
nucleotide ✗ many -_
'
HI tinker Protein
+
on-ryiningt.ve charge
=
nucleic acid -
mosttue charge
OCPG Islands control gene expression via
methylation and acetylation
t
ANTI -
parallel Fighters relaxes
NITROGENOUS BASE : PENTOSE SUGAR : NUCLEOTIDE :
puosphate@ctty_oy_5-Buse-sh-uanineg.ro
Adenine ,
→ ☒ y
☐
purine ° RIBOSE
up
""
0
Deoxyribose 1-
-79" I
OH
☐
pyrimidine pentose sugar
→ uracil
→ Thymine
" -
bonds
A T
G- = C
PHARMACOLOGY
PURINE / PYRIMIDIN INHIBITOR :
Drugs that inhibit DNA synthesis
☐ Antimetabolite, º Antimetabolites
- e.g 5-fluorouracil, methotrexate, 6-mercaptopurine
-
5
, fluorouracil - inhibits nucleic acid base synthesis
- methotrexate inhibits dihydrofolate reductase, preventing folate
6 , mecapwpurine
cycling
-
- 5fluorouracil forms an inhibitor of thymidyate synthase
-
methotrexate - so methotrexate and 5FU inhibit pyrimidine synthesis
- methotrexate also inhibits purine synthesis
- 6mercaptopurine forms an inhibitor of IMP dehydrogenation/
deamination, inhibits Purim synthesis
- therefore inhibiting DNA synthesis
:
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