HCOZ :
Introduction TO The immune System
immune
System
-
(An
Identity Threat ( NO elimination of self )
it builds
-
A
Memory
firsi Protection → barrier,
PHYSICAL : Shin HAIR nails mucosa
-
,
, ,
° "
Aniimicrobial ten.rs/salivA
→ VA INA
Chemical : Substances epiihelium , lysozyme in acid
-
,
immune
System
-
protein in blood
leukocyies
-
for
cytokines → secreied Communication
-
↳
interleuhins Cheindsines interferon S
, ,
INNATE → f- AST non specific , no improvement, no
Memory
-
,
ys
Adaptive → slow , highly specific , improves with Tine
, Memory
INNATE
-
effector Mechanism → eliminatie
pathogeen ( by leukocyten & plasma protein )
cells
important phagocyies
-
→
granulocyten → firsi Arrive
-
TO
of
helpt the lenhrocyies
-
complement =
System plasma protein
→
labels the
pathogeen
vhyeloid cells
binding
-
eating
-
secreting cytokines
-
Adaptive
W W W →
Wa Wa Wa
W w µ
.
W W
→
Wa
T
B cells & cells dendriiic cells
T
macrophages
-
And +
MHC is used
Antigen b APC
-
TO
present
TCR only Tcell BCR Also Aniibody
-
on AS
,
Aften clonal
STAY behind
few cells
-
expansion A
↳ Formation
Memory
ijIJ
, lymph organs
Thymus → T cells edncrtted
-
-
bone Marrow →
TIB cells made
lymph nodes →
hubs for immune cells
-
inflammrttion
goals
-
-
eliminatie G- use
-
Clearing Oui necrotic cells
Tissue other cells
Repair
( easily
-
can enter more
Cytokines
histamine
first Cells
macrophage Coll ↑ VASCUIAR
pervneabiliiy
signalling
→
-
: + MAST → serotonine
,
mobilize
Systemic Cytokines immune
System
↳ =
fever
HCO} :
mechanismes of innate
immunity
And Adaptive work
INNATE
immunity Together
↳ induce inf / Animation cells molecules of of infection / Tissue
brings And immune
damage
→
System to site
innate immune
System
-
bio -
Mechanical barrier
-
skin
MUCOSA
-
-
soluble protein
-
Anti -
microbi.nl pepíides
Complement
-
cytokines / cheinohines
-
Acute Phase proieins
-
-
cells
grannlocyìes
-
Macrophages
-
different innate defense Mechanism for different Infectious
↳ firsi Cytokines
, complement
-
Cascade of soluble protiens And ( ell -
bound receptor And inhibitors
mainly present in serum
-
-
producen by Variety
of cell
Types
→ mist
b hepatocyies
-
function
hill
pn-i-hogens-opsoniZAT.vn
-
ACTIVATES Adaptive immunity
-
ACÏNATIOV Of complement
-
CLASSICAL
-
immune complexe And APOPTOTIC cells
(
1g
-
-
leciin
(
Arbohydrties And
IgA
-
-
MBL
-
Alternative
bn-cieri.nl surfaces LPS
And
IgA
-
-
↳ H2O
→ AII ACTIVATE (3
eventually → After The same Mechanism
(3 Splits in
-
( 3A → cheMOTAX.is
-
(3b →
OPSONISATION
Terminal PATHWAY = ( Sb 9-
( MAC) →
lysis
of ( Sb (3
clen-vn.ge Cs into ↳ ( ONVERTASE
-
-
-
( Sb binds (6 (7 (8 And multiple copies of (9
, ,
↳ forms Which
A
pore ,
Causes A cell To become leahy →
lysis
many complement inhibitors
ATTACK het / cells
STOPS spontane ons complement ACTIUATION And
Ing 0Wh
Thy
-
deficient of Clinical
juist Presentation
-
one →
effect or Mechanism of complement
-
ACTIVATIOVI Of in HAMMATIONS
( Csa ( Sa) Huid
-
Anaphylatoxins And →
incren.se vasculair permertbiliìy →
leakage And monocyteneutrophil Migration
of microbe
b phagocyies
recognition
-
(3b
opsonization b
-
-
lysis → membrane ATTACK complex ( MAC )
ij
