MOOC : Introduction TO immune
System
defends
immune
System AGAINST pathogeen
cells
INNATE →
macrophages ,
neutrophils ,
Nk
,
complement , cytokines
Adaptive →
lymfocyt es ,
Anti bodies
MHC Presents pepiides TO
lymfocyt es → ATTACK +
Memory Formation
→ Shor t pepiides
↳ hp TO 25 Animo Acids
MOOC :
The humoral immune
System
B- cell receptor = Aniibodies
VD
] have multiple ( variable par t)
-
Segment options
CAN wiihoui MHC
-
Recognize epitope
has multiple ( IgM IgG IgA IGD )
IgG
-
CONSTANT PART isotypes , , , ,
Memory response is quicker And
langer
MOOC :
histocompatibility
HLA = MOST important Target of immune System in donor
Organ
↑ A. B. DR Are Tested
is but hard ( is Optimal )
→
Matching important 0 0 0
- -
,
→ mismatch is possible ,
if previous exposure has not happened ( blood TRANS fusion
, Pregnancy ,
TRANSPIANT )
MOOC
immunogenetics
:
TRANSPIANTATION needs immunosupressive drugs ( except if donor is
monozygotic Twin )
human leukocyten HLA
Antigen
=
Serological Typing TERAZAGI If lysis of
lymphocyies
-
→
Tray , positive
Molecular Identity The HLA DNA
-
→ in
Typing Type
-
Short Ar m Chromosomen 6
-
Class 1 → A B C
, ,
-
Class 11 → DR DQ DP
, ,
HLA
in family → 25 % chance of identiek Type
in
general population → much lower
,MOOC : The
Kidney in health And disease
netron
glomerulus proxima /
Renint EPO Thbnll
f)
inaciive → Active UITD
[
uit ☐
funciions : excretion HOMEOSTASIS ,
Production Conversion
, ,
disial
Tubnle
Sympioms Kidney disease
colleciing
Tube
-
ACCUMUIATION Of WASTE Products
-
Fluid Overload And electro/ disiurbances
yie
-
↑ blood pressure
-
Anemia ' ◦OP ◦t Henk
cor tex
meduy ,
-
bone disease
Renat function other
Measurement
diagnosiics
men : 60 -
110 mmol / L
Serum creatinine →
wonnen 50 100 µmol / L urine Analysis
- -
:
-
GFR >
60 mL / min / 1.73 m2 ( ulirasound)
Imaging
-
→ -
CIEARANCE
creatinine → 70 110 mL / min / 1.73 m2 RENAI
biopsy
-
- -
Causes of Renat failure
-
prerenal → 10W blood pressure , heari failure
Renat glomerulonephritis
-
→
POSTREUAI → Obstruction of TRACT
urinary
-
Chronic
Kidney disease Kidney GFR 60 for >
3 months
damage
<
=
or
has 5
Stages
-
diabetes And
hypertension Main Causes
-
Are
MOOC :
options if hiidneys fail
ESRD TREATMENT
Conservative →
Antihypertensive mediation
-
dialysis disn-dvantn-g.es dialysis
-
hemodialyse's lower quality of life
-
-
-
periìoneal dialysis
-
it can t
'
fully Replace Kidney function
Renal Transplantaties high morbidity / /
ity
- -
MORTA
-
decertsed donor DISADUANTAGES Transplantaties
-
donation After brain death ( DBD )
-
Surgical COMPIICATIONS
-
donation Aften
CIRCUIATORY de Ath ( DCD ) -
Risk of AIIOGRAFT Rejeciion
-
living donor
-
Iitelong need for medications
-
Related -
side effects immunosuppressanis
of
Related Risk
AIIOGRAFT disfunciion
-
un
-
-
Altruisiic
of
PART Exchange Program
-
